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Open AccessArticle

In Vitro Protective Effect of Paste and Sauce Extract Made with Protaetia brevitarsis Larvae on HepG2 Cells Damaged by Ethanol

1
Department of Integrative Biological Sciences and Industry, Sejong University, Seoul 05006, Korea
2
Department of Biochemistry, School of Medicine, Dongguk University, Gyeongju, Kyeongbuk 38066, Korea
*
Author to whom correspondence should be addressed.
Insects 2020, 11(8), 494; https://doi.org/10.3390/insects11080494
Received: 4 June 2020 / Revised: 15 July 2020 / Accepted: 28 July 2020 / Published: 3 August 2020
We made paste and sauce using protein-rich Protaetia brevitarsis larvae (PBL) and evaluated their fermentation levels. After pretreatment with the paste and sauce extracts, HepG2 cells were damaged with ethanol (EtOH), and then the effects of the paste and sauce were evaluated. As a result, we confirmed that the PBL paste and sauce extracts reduced the aspartate aminotransferase (AST) and alanine aminotransaminase (ALT) content in the medium as compared to soybean (Glycine max) sauce and paste extracts. In addition, the PBL paste and sauce extracts significantly lowered the level of tumor necrosis factor (TNF)-α and interleukin (IL)-6, which are biomarkers of inflammation, and significantly increased the inhibition rate of superoxide dismutase (SOD) and reduced glutathione (GSH), which are antioxidative indicators, in proportion to the amount of PBL added to the paste and sauce. These results suggest that an intake of PBL paste and sauce, a novel type of fermented food made from insects, may be effective for liver protection through anti-inflammatory and antioxidative effects against hepatocyte injury caused by EtOH. View Full-Text
Keywords: Protaetia brevitarsis; paste; sauce; hepatoprotective Protaetia brevitarsis; paste; sauce; hepatoprotective
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MDPI and ACS Style

Hwang, D.; Goo, T.-W.; Yun, E.-Y. In Vitro Protective Effect of Paste and Sauce Extract Made with Protaetia brevitarsis Larvae on HepG2 Cells Damaged by Ethanol. Insects 2020, 11, 494. https://doi.org/10.3390/insects11080494

AMA Style

Hwang D, Goo T-W, Yun E-Y. In Vitro Protective Effect of Paste and Sauce Extract Made with Protaetia brevitarsis Larvae on HepG2 Cells Damaged by Ethanol. Insects. 2020; 11(8):494. https://doi.org/10.3390/insects11080494

Chicago/Turabian Style

Hwang, Dooseon; Goo, Tae-Won; Yun, Eun-Young. 2020. "In Vitro Protective Effect of Paste and Sauce Extract Made with Protaetia brevitarsis Larvae on HepG2 Cells Damaged by Ethanol" Insects 11, no. 8: 494. https://doi.org/10.3390/insects11080494

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