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Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus

Infection and Innate Immunity Lab, Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
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Insects 2020, 11(2), 85; https://doi.org/10.3390/insects11020085
Received: 26 December 2019 / Revised: 22 January 2020 / Accepted: 23 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue Insects, Nematodes and Their Symbiotic Bacteria)
The fruit fly Drosophila melanogaster forms a magnificent model for interpreting conserved host innate immune signaling and functional processes in response to microbial assaults. In the broad research field of host-microbe interactions, model hosts are used in conjunction with a variety of pathogenic microorganisms to disentangle host immune system activities and microbial pathogenicity strategies. The pathogen Photorhabdus is considered an established model for analyzing bacterial virulence and symbiosis due to its unique life cycle that extends between two invertebrate hosts: an insect and a parasitic nematode. In recent years, particular focus has been given to the mechanistic participation of the D. melanogaster thioester-containing proteins (TEPs) in the overall immune capacity of the fly upon response against the pathogen Photorhabdus alone or in combination with its specific nematode vector Heterorhabditis bacteriophora. The original role of certain TEPs in the insect innate immune machinery was linked to the antibacterial and antiparasite reaction of the mosquito malaria vector Anopheles gambiae; however, revamped interest in the immune competence of these molecules has recently emerged from the D. melanogaster-Photorhabdus infection system. Here, we review the latest findings on this topic with the expectation that such information will refine our understanding of the evolutionary immune role of TEPs in host immune surveillance.
Keywords: Drosophila melanogaster; thioester-containing proteins; Photorhabdus; Heterorhabditis; humoral immunity; cellular immunity; metabolism; infection Drosophila melanogaster; thioester-containing proteins; Photorhabdus; Heterorhabditis; humoral immunity; cellular immunity; metabolism; infection
MDPI and ACS Style

Eleftherianos, I.; Sachar, U. Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus. Insects 2020, 11, 85.

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