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Open AccessArticle

Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells

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Metallurgical and Materials Engineering Department, University of Texas at El Paso, El Paso, TX 79968, USA
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Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USA
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Biological Science Department, University of Texas at El Paso, El Paso, TX 79968, USA
*
Author to whom correspondence should be addressed.
Academic Editor: James E. Krzanowski
Lubricants 2015, 3(3), 597-610; https://doi.org/10.3390/lubricants3030597
Received: 1 June 2015 / Revised: 27 June 2015 / Accepted: 22 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Tribological Performance of Artificial Joints)
Carbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwall carbon nanotubes in biomaterials contacting with bone. This study describes the response of murine macrophage-like Raw 264.7 cells after two and six days of culture in contact with artificially generated particles from both, ultra-high molecular weight polyethylene polymer and the composite (multiwall carbon nanotubes and ultra-high molecular weight polyethylene). This novel composite has superior wear behavior, having thus the potential to reduce the number of revision knee arthroplasty surgeries required by wear failure of tibial articulating component and diminish particle-induced osteolysis. The results of an in vitro study of viability, and interleukin-6 and tumor necrosis factor-alpha production suggest good cytocompatibility, similar to that of conventional ultra-high molecular weight polyethylene. View Full-Text
Keywords: in vitro macrophages response; knee replacement; multiwall carbon nanotubes; ultra-high molecular weight polyethylene; wear debris cytotoxicity in vitro macrophages response; knee replacement; multiwall carbon nanotubes; ultra-high molecular weight polyethylene; wear debris cytotoxicity
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Camacho, N.; Stafford, S.W.; Garza, K.M.; Suro, R.; Barron, K.I. Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells. Lubricants 2015, 3, 597-610.

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