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J. Pers. Med. 2019, 9(1), 5; https://doi.org/10.3390/jpm9010005

The Emerging Role of Checkpoint Inhibition in Microsatellite Stable Colorectal Cancer

1
Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
2
Division of Hematology/Oncology, Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Received: 30 November 2018 / Revised: 5 January 2019 / Accepted: 11 January 2019 / Published: 16 January 2019
(This article belongs to the Special Issue Biomarkers in Colorectal Cancer)
Full-Text   |   PDF [810 KB, uploaded 16 January 2019]   |  

Abstract

Checkpoint inhibitor therapy has introduced a revolution in contemporary anticancer therapy. It has led to dramatic improvements in patient outcomes and has spawned tremendous research into novel immunomodulatory agents and combination therapy that has changed the trajectory of cancer care. However, clinical benefit in patients with colorectal cancer has been generally limited to tumors with loss of mismatch repair function and those with specific germline mutations in the DNA polymerase gene. Unfortunately, tumors with these specific mutator phenotypes are in the minority. Recent pre-clinical and clinical studies have begun to reveal encouraging results suggesting that checkpoint inhibitor therapy can be expanded to an increasing number of colorectal tumors with microsatellite stability and the absence of traditional predictive biomarkers of checkpoint inhibitor response. These studies generally rely on combinations of checkpoint inhibitors with chemotherapy, molecular targeted therapy, radiation therapy, or other novel immunomodulatory agents. This article will review the most current data in microsatellite stable colorectal cancer. View Full-Text
Keywords: immunotherapy; microsatellite stable; colorectal cancer; immune checkpoint inhibitors immunotherapy; microsatellite stable; colorectal cancer; immune checkpoint inhibitors
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Hermel, D.J.; Sigal, D. The Emerging Role of Checkpoint Inhibition in Microsatellite Stable Colorectal Cancer. J. Pers. Med. 2019, 9, 5.

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