Next Article in Journal
Re-Examining Genetic Screening and Oral Contraceptives: A Patient-Centered Review
Previous Article in Journal
Association of TLR4 Polymorphisms, Expression, and Vitamin D with Helicobacter pylori Infection
Open AccessReview

Colorectal Cancer Biomarkers in the Era of Personalized Medicine

1
Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC 28204, USA
2
Department of Pharmacy, Levine Cancer Institute, Atrium Health, Charlotte, NC 28204, USA
3
Department of Solid Tumor Oncology, Levine Cancer Institute, Atrium Health, Charlotte, NC 28204, USA
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2019, 9(1), 3; https://doi.org/10.3390/jpm9010003
Received: 3 December 2018 / Revised: 10 January 2019 / Accepted: 10 January 2019 / Published: 14 January 2019
The 5-year survival probability for patients with metastatic colorectal cancer has not drastically changed over the last several years, nor has the backbone chemotherapy in first-line disease. Nevertheless, newer targeted therapies and immunotherapies have been approved primarily in the refractory setting, which appears to benefit a small proportion of patients. Until recently, rat sarcoma (RAS) mutations remained the only genomic biomarker to assist with therapy selection in metastatic colorectal cancer. Next generation sequencing has unveiled many more potentially powerful predictive genomic markers of therapy response. Importantly, there are also clinical and physiologic predictive or prognostic biomarkers, such as tumor sidedness. Variations in germline pharmacogenomic biomarkers have demonstrated usefulness in determining response or risk of toxicity, which can be critical in defining dose intensity. This review outlines such biomarkers and summarizes their clinical implications on the treatment of colorectal cancer. It is critical that clinicians understand which biomarkers are clinically validated for use in practice and how to act on such test results. View Full-Text
Keywords: biomarker; prognostic; predictive; somatic; germline; pharmacogenomics; personalized medicine biomarker; prognostic; predictive; somatic; germline; pharmacogenomics; personalized medicine
MDPI and ACS Style

Patel, J.N.; Fong, M.K.; Jagosky, M. Colorectal Cancer Biomarkers in the Era of Personalized Medicine. J. Pers. Med. 2019, 9, 3.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop