The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine
Abstract
:1. Introduction
Medical History |
Alzheimer’s OR Dementia |
Ischemic Heart Disease (coronary artery disease (CAD), coronary heart disease, ischemic cardiomyopathy) |
Cerebrovascular Disease (stroke, TIA, embolism, aneurysm, other circulatory disorder affecting the brain) |
Heart attack, acute myocardial infarction, acute coronary syndrome |
Renal Failure |
Nephritis, Nephrotic Syndrome and/or Nephrosis |
Chronic Respiratory Disease (Chronic Obstructive Pulmonary Syndrome (COPD) OR Chronic Lower Respiratory Disease (CLRD) (chronic bronchitis, emphysema)) |
Chronic Lower Respiratory Disease |
Influenza (acute viral infection including avian influenza) |
Pneumonia (acute respiratory infection affecting the lungs) |
Diabetes mellitus type 1 (IDDM, formerly juvenile diabetes) |
Diabetes mellitus type II (NIDDM, adult onset diabetes) |
Uremia (Kidney Disorder) |
Bacterial Infections (including septicemia (bacteria in the blood), meningococcal disease, staphylococcal infection, streptococcus, sepsis) |
Liver Disease (liver abscess, failure, fatty liver syndrome, inherited liver insufficiency, acute/chronic hepatic insufficiency, necrobacillosis, rupture) |
Arthritis |
Major depression (unipolar depression, major depressive disorder) |
Asthma |
Hypertension |
Parkinson’s |
Schizophrenia |
Crohn’s Disease |
Gastric Reflux Disease, reflux esophagitis, heartburn, GERD |
Atrial Fibrilation |
Sjogren’s Disease (chronic dry mouth/dry eyes) |
Diverticular Disease, diverticulitis |
Ulcerative Colitis |
Other data |
Current Medications |
Medication Name/Vitamins/Supplements |
Death Circumstances |
Is death certificate available |
Date and time pronounced dead |
Date and time of actual (witnessed) death |
Date and time of presumed death |
Date and time last seen alive |
Place of Death |
If death occurred outside of hospital, who determined date/time of death |
Manner of Death |
Death Classification: 4-point Hardy Scale |
Did Coroner/ME Perform an Autopsy? |
Was donor on a ventilator immediately prior to Death |
If yes, specify duration (hours) |
Death Certificate Cause of Death |
Immediate Cause of Death |
Approximate Interval: Onset to Death(hours) |
First underlying Cause of Death |
Approximate Interval: Onset to Death(hours) |
Last Underlying Cause of Death |
Was the body refrigerated at any time before procurement? |
if yes, estimate number of hours in refrigeration (hours) |
Organ Donor (OPO) Type |
Serology Report |
HIV I/II Ab |
HIV I/II Plus O Antibody |
HBsAg |
HBsAb |
HBcAb (Total; IgG+IgM) |
HBcAb-IgM |
HCV Ab |
EBV IgG Ab |
EBV IgM Ab |
RPR |
CMV Total Ab |
HIV-1 NAT |
HCV-1 NAT |
PRR/VDRL |
2. Specimen Collection, Clinical Data Elements, and Biospecimen Quality
Biospecimen Quality
3. Anticipated Findings
3.1. Expression Quantitative Trait Loci (eQTLs)
3.2. Accessing the Samples: The GTEx Portal
4. Conclusions
Acknowledgements
Author Contributions
Conflicts of Interest
References
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© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Keen, J.C.; Moore, H.M. The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine. J. Pers. Med. 2015, 5, 22-29. https://doi.org/10.3390/jpm5010022
Keen JC, Moore HM. The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine. Journal of Personalized Medicine. 2015; 5(1):22-29. https://doi.org/10.3390/jpm5010022
Chicago/Turabian StyleKeen, Judy C., and Helen M. Moore. 2015. "The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine" Journal of Personalized Medicine 5, no. 1: 22-29. https://doi.org/10.3390/jpm5010022