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Open AccessCommentary

The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine

Biorepositories and Biospecimen Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
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Academic Editor: Lori A. Orlando
J. Pers. Med. 2015, 5(1), 22-29; https://doi.org/10.3390/jpm5010022
Received: 24 October 2014 / Revised: 31 December 2014 / Accepted: 28 January 2015 / Published: 5 February 2015
(This article belongs to the Special Issue Biobanking and EHR/EMR)
Evaluation of how genetic mutations or variability can directly affect phenotypic outcomes, the development of disease, or determination of a tailored treatment protocol is fundamental to advancing personalized medicine. To understand how a genotype affects gene expression and specific phenotypic traits, as well as the correlative and causative associations between such, the Genotype-Tissue Expression (GTEx) Project was initiated The GTEx collection of biospecimens and associated clinical data links extensive clinical data with genotype and gene expression data to provide a wealth of data and resources to study the underlying genetics of normal physiology. These data will help inform personalized medicine through the identification of normal variation that does not contribute to disease. Additionally, these data can lead to insights into how gene variation affects pharmacodynamics and individualized responses to therapy. View Full-Text
Keywords: biobanking; biorepository; tissue biospecimen; gene variation; genotype; Genotype-Tissue Expression biobanking; biorepository; tissue biospecimen; gene variation; genotype; Genotype-Tissue Expression
MDPI and ACS Style

Keen, J.C.; Moore, H.M. The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine. J. Pers. Med. 2015, 5, 22-29.

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