Hallux Sesamoid Nonunion: A Comprehensive Systematic Review of Current Evidence
Abstract
1. Introduction
2. Materials and Methods
- Absence of postoperative objective outcome data;
- Studies involving patients with various sesamoid disorders where specific data on nonunion were not distinguishable (mixed population);
- Studies reporting fractures unhealed for less than nine months (the most commonly agreed-upon standard definition [14]) unless nonunion was explicitly stated;
- Articles not published in English;
- Cadaveric studies, case reports, technical notes, narrative reviews, editorials, or surgical technique articles lacking outcome data.
- First author and year of publication;
- Study design and corresponding Level of Evidence (LOE);
- Number of patients and feet, mean age at time of surgery, sex distribution, and affected sesamoid;
- Type of surgical intervention, bone graft harvest site (if applicable), percentage of successful unions, mean time to radiographic union, and duration of follow-up;
- Preoperative and postoperative clinical outcomes;
- Complications and any subsequent reinterventions.
Statistical Analysis
3. Results
3.1. Type of Studies
3.2. Population
3.3. Surgical Procedures
3.4. Radiological and Clinical Results
3.5. Complications and Any Subsequent Reinterventions
4. Discussion
Limitation
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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SELECTION | COMPARABILITY | OUTCOME | |||||||
---|---|---|---|---|---|---|---|---|---|
Authors and Years | Representativeness of cases | Selection of controls | Ascertainment of exposure | Demonstration that outcome of interest was not present at start of study | Assessment of Outcome | Follow-Up Long Enough | Adequacy of Follow-Up | Total | |
Anderson R.B. et al., 1997 [11] | - | - | ★ | ★ | - | ★ | ★ | ★ | 5★ |
Bichara D.A. et al., 2012 [16] | - | - | ★ | ★ | - | ★ | ★ | ★ | 5★ |
Blundell C.M. et al., 2002 [15] | - | - | ★ | ★ | - | ★ | - | ★ | 4★ |
Levaj I. et al., 2021 [17] | - | - | ★ | ★ | - | ★ | - | ★ | 4★ |
Nakajima K. et al., 2022 [19] | - | - | ★ | ★ | - | ★ | ★ | ★ | 5★ |
Park Y.H. et al., 2024 [18] | - | - | ★ | ★ | - | ★ | - | ★ | 4★ |
Authors-Years | Study Design and LOE | Number of Feet (n. Patients) | Age at Treatment (Years) | Gender F:M | Affected Sesamoid | Surgical Procedure | Bone Graft Harvest Site |
---|---|---|---|---|---|---|---|
Anderson R.B. et al., 1997 [11] | Retrospective case series (IV) | 21 (21) | 32.9 | 10F:11M | - 21 tibial | Open autologous bone grafting | Ipsilateral medial eminence of the first metatarsal head |
Bichara D.A. et al., 2012 [16] | Retrospective case series (IV) | 24 (24) | 32.2 ± 10.4 (17–54) | - | - 15 tibial - 9 fibular | Open sesamoidectomy | - |
Blundell C.M. et al., 2002 [15] | Retrospective case series (IV) | 9 (9) | 26 ± 7.0 (17–45) | 3F:6M | - 5 tibial - 4 fibular | Percutaneous fixation with Barouk screw | - |
Levaj I. et al., 2021 [17] | Retrospective case series (IV) | 5 (5) | 21.2 ± 6.2 (14–39) | 5F:0M | - 3 tibial - 2 fibular | Arthroscopic sesamoidectomy | - |
Nakajima K. et al., 2022 [19] | Retrospective case series (IV) | 11 (11) | 18.6 ± 10.3 (13–49) | 3F:8M | - 9 tibial - 1 fibular - 1 distal part of congenital bipartite sesamoid | Arthroscopic autologous bone grafting | Iliac crest |
Park Y.H. et al., 2024 [18] | Retrospective case series (IV) | 10 (10) | 39.4 ± 14.0 (23–62) | 6F:4M | - 9 tibial - 1 fibular | Open screw fixation and autologous bone grafting | Ipsilateral calcaneus |
Total | 80 (80) | 30.0 (17–62) | 37F:29M | - 62 tibial - 17 fibular - 1 congenital bipartite sesamoid |
Authors and Years | Number of Feet (n. Patients) | Age at Treatment (Years) | Postoperative Management | Return to Sport/Activity (Months) |
---|---|---|---|---|
Anderson R.B. et al., 1997 [11] | 21 (21) | 32.9 | The patient was placed immediately into a short leg plaster splint. The patient remained non-weight-bearing for a period of 3 to 4 weeks, at which time a short leg walking cast was applied, again immobilizing the hallux. The cast was removed at 8 weeks. A soft, medial longitudinal arch support was prescribed and was used in conjunction with a firm-soled shoe. Active exercises were initiated, followed by gentle passive range of motion as symptoms permitted. | - |
Bichara D.A. et al., 2012 [16] | 24 (24) | 32.2 ± 10.4 (17–54) | The patients were instructed to begin weight-bearing as tolerated in a postoperative shoe with crutches for 7 to 10 days. Some patients used a removable walking boot for an additional 2 weeks. | 2.9 ± 0.97 (2–6) |
Blundell C.M. et al., 2002 [15] | 9 (9) | 26 ± 7.0 (17–45) | Patients were mobilized with two crutches for one week, bearing weight as tolerated. They were then allowed to bear weight fully without aids. Running was allowed at six weeks with a gradual return to full activity at three months. | 6.0 |
Levaj I. et al., 2021 [17] | 5 (5) | 21.2 ± 6.2 (14–39) | All patients started with gentle passive range-of-motion exercises for the first MTP joint at PDO 3. At the end of the second postoperative week, the patients started with active and active-assisted ROM exercises for the first MTP joint. Strengthening and ROM exercises were initiated at the fourth postoperative week. For the first three postoperative weeks, the patients walked with the aid of two crutches and were allowed to bear weight as tolerated in a removable short-leg walking splint with a rocker sole. For the next six weeks, the patients were instructed to wear rocker bottom shoes. At that time, patients started to wear regular shoes. Patients returned progressively to sports three to six months after the surgery. | - |
Nakajima K. et al., 2022 [19] | 11 (11) | 18.6 ± 10.3 (13–49) | Passive plantar flexion of the hallux at PDO 1. Passive dorsiflexion and active plantar flexion were not allowed until 6 weeks after surgery. Walking with a postoperative shoe was started at PDO 1 until 6 weeks after surgery. Sport activities were initiated after confirmation of complete union at CT. | 5.3 ± 3.6 (2–15) |
Park Y.H. et al., 2024 [18] | 10 (10) | 39.4 ± 14.0 (23–62) | A short leg splint was applied to immobilize the foot for 2 weeks, and patients were instructed on non-weight-bearing crutch walking. Subsequently, the splint was removed, and heel weight-bearing was allowed for 4 weeks. At 6 weeks postoperatively, the patients were transitioned to full weight-bearing and started physical therapy to improve the first metatarsophalangeal joint range of motion. Running was allowed at 8–10 weeks postoperatively, with a gradual return to full activity at 3 months. | 9.9 ± 3.8 |
Total | 80 (80) | 30.0 (17–62) | 5.2 (2–15) |
Authors and Years | Achieved Union | Average Time Until Bone Union (Months) | Follow-Up (Months) | VAS | Clinical Scores | Return to Sport/Activity (Months) | Complications | Reoperations |
---|---|---|---|---|---|---|---|---|
Anderson R.B. et al., 1997 [11] | 90.5% | 3.0 | 56 ± 27.2 (23–132) | - | - | - | - 2 persistent pain and tenderness (persistent nonunion) - 1 paresthesia along the course of the medial plantar digital nerve | - 2 sesamoidectomy (persistent nonunion) - 1 bunion correction (premorbid condition with HVA and IMA not progressed since the time of sesamoid grafting) |
Bichara D.A. et al., 2012 [16] | - | - | 35 21 (8–70) | Pre-op. 62.0 ± 14.0, post-op. 7 ± 10 | - | 2.9 ± 0.97 (2–6) | - 1 patient developed a symptomatic hallux valgus deformity after the resection of the medial sesamoid - 1 persistent pain | No reoperations needed |
Blundell C.M. et al., 2002 [15] | - | - | 6.0 | - | - AOFAS: pre-op. 46.9 ± 9.75 (25–64) post-op. 80.7 | 6.0 | No complications observed | No reoperations needed |
Levaj I. et al., 2021 [17] | - | - | 20.6 ± 12.5 (4–54) | - | - | No complications observed | No reoperations needed | |
Nakajima K. et al., 2022 [19] | 100% | 2.9 ± 0.8 (2–4) | 38.4 ± 9.6 (25.2–57.6) | Pre-op. 72.1 ± 15.2 (50–100), post-op. 12 ± 26.7 (0–70) | - JSSF: pre-op. 58.7 ± 15.8 (42–87) post-op. 95.0 ± 11 (69–100) | 5.3 ± 3.6 (2–15) | No complications observed | -1 arthroscopic sesamoidectomy (patient with affected fibular sesamoid and hypoplastic tibial sesamoid) |
Park Y.H. et al., 2024 [18] | 100% | 3.0 | 23.4 ± 14.5 (12–61) | Pre-op. 67.8 ± 13.5, post-op. 3.6 ± 4.8 | - FFI: pre-op. 72.3 ± 8.7 post-op. 8.2 ± 8.3 | 9.9 ± 3.8 | No complications observed | - 2 hardware removal due to discomfort and anxiety |
Total | 96.8% | 2.95 (2–4) | 35.4 (4–61) | Pre-op. 65.75, post-op. 7.46 | 5.2 (2–15) | 6.25% | 6.25% |
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Artioli, E.; Mazzotti, A.; Di Paola, G.; Sgubbi, F.; Gemini, G.; Zielli, S.O.; Faldini, C. Hallux Sesamoid Nonunion: A Comprehensive Systematic Review of Current Evidence. J. Pers. Med. 2025, 15, 342. https://doi.org/10.3390/jpm15080342
Artioli E, Mazzotti A, Di Paola G, Sgubbi F, Gemini G, Zielli SO, Faldini C. Hallux Sesamoid Nonunion: A Comprehensive Systematic Review of Current Evidence. Journal of Personalized Medicine. 2025; 15(8):342. https://doi.org/10.3390/jpm15080342
Chicago/Turabian StyleArtioli, Elena, Antonio Mazzotti, Gianmarco Di Paola, Federico Sgubbi, Gianmarco Gemini, Simone Ottavio Zielli, and Cesare Faldini. 2025. "Hallux Sesamoid Nonunion: A Comprehensive Systematic Review of Current Evidence" Journal of Personalized Medicine 15, no. 8: 342. https://doi.org/10.3390/jpm15080342
APA StyleArtioli, E., Mazzotti, A., Di Paola, G., Sgubbi, F., Gemini, G., Zielli, S. O., & Faldini, C. (2025). Hallux Sesamoid Nonunion: A Comprehensive Systematic Review of Current Evidence. Journal of Personalized Medicine, 15(8), 342. https://doi.org/10.3390/jpm15080342