Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer

Yorozu, Kensho; Kaibori, Masaki; Kimura, Shintarou; Ichikawa, Misa; Matsui, Kosuke; Kaneshige, Soichiro; Kobayashi, Masanori; Jimbo, Daiki; Torikai, Yusuke; Fukuzawa, Yoshitaka; Okamoto, Yoshiharu

doi:10.3390/jpm12071039

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Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer

^1,*,†

^2,†

³,

³,

²,

⁴,

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¹,

⁶ and

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Yorozu Clinic, 1-118-4 Mihagino, Tottori 689-0202, Japan

Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1191, Japan

StateArt Inc., StateArt Bild 2-9-12 Nihonbashi Horidomecho, Chuo-ku, Tokyo 103-0012, Japan

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Department of Radiation Oncology, Okayama Central Hospital, 6-3 Ishimakitamachi, Okayama 700-0017, Japan

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Serenclinic-Nagoya, 2F, Hisaya Park Bld, 4-14-2 Sakae, Naka-ku, Nagoya, Aichi 460-0008, Japan

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Aichi Medical University Hospital Preemptive & Integrative Medicine Center 1-1, Iwasaku Karimata, Nagakute, Aichi 480-1195, Japan

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Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, Tottori 680-8553, Japan

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Academic Editor: Kyung-Han Lee

J. Pers. Med. 2022, 12(7), 1039; https://doi.org/10.3390/jpm12071039

Received: 4 May 2022 / Revised: 23 June 2022 / Accepted: 23 June 2022 / Published: 24 June 2022

(This article belongs to the Section Personalized Therapy and Drug Delivery)

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Abstract

We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy. ICG liposomes were prepared by adding 5 mg of ICG to 50 mL liposomes. Later, 25 mL of ICG liposomes were diluted with 250 mL of 5% glucose solution and administered intravenously to the patient. We selected the multi-laser delivery system (MLDS), a laser irradiator for performing PDT. Further, the patients received a combination of LEM and hydrogen gas inhalation therapy throughout the treatment. We reported two cases of PDT therapy, one with middle intrathoracic esophagus carcinoma and the other with hypopharyngeal cancer. In the first case, the MLDS laser was directly attached to the endoscope and directed to the cancer area with wavelengths of 810 nm. After the treatment, a biopsy demonstrated no tumor recurrence. In the second case, the patient was treated with endovascular PDT using ICG liposomes and MLDS fiber optics. Later, tumor shrinkage was demonstrated after the first round and disappeared after six months. In conclusion, the present findings suggest that the effect of PDT using ICG liposomes with LEM and hydrogen gas may eradicate cancer without burdening patients by enhancing tumor immunity. View Full-Text

Keywords: photodynamic therapy; indocyanine green liposomes; multi-laser delivery system; Lentinula edodes mycelia; hydrogen gas; esophagus carcinoma; hypopharyngeal cancer

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MDPI and ACS Style

Yorozu, K.; Kaibori, M.; Kimura, S.; Ichikawa, M.; Matsui, K.; Kaneshige, S.; Kobayashi, M.; Jimbo, D.; Torikai, Y.; Fukuzawa, Y.; Okamoto, Y. Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer. J. Pers. Med. 2022, 12, 1039. https://doi.org/10.3390/jpm12071039

AMA Style

Yorozu K, Kaibori M, Kimura S, Ichikawa M, Matsui K, Kaneshige S, Kobayashi M, Jimbo D, Torikai Y, Fukuzawa Y, Okamoto Y. Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer. Journal of Personalized Medicine. 2022; 12(7):1039. https://doi.org/10.3390/jpm12071039

Chicago/Turabian Style

Yorozu, Kensho, Masaki Kaibori, Shintarou Kimura, Misa Ichikawa, Kosuke Matsui, Soichiro Kaneshige, Masanori Kobayashi, Daiki Jimbo, Yusuke Torikai, Yoshitaka Fukuzawa, and Yoshiharu Okamoto. 2022. "Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer" Journal of Personalized Medicine 12, no. 7: 1039. https://doi.org/10.3390/jpm12071039

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