Clinical and Virological Characteristics and Prognostic Factors in Viral Necrotizing Retinitis

Round 1

Reviewer 1 Report

This is a very interesting study about an unfrequent and poorly recognized viral retinal disease with dramatic consequences if left untreated. I have no specific comments pertaining to this manuscript.

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

However, the presented topic is interesting and important for ophthalmologists, the paper was not presented in a reader friendly way. In some paragraphs, the authors did not put references; tables are very long and hard to understand; the subjects did not characterize enough etc.; sample size calculation is needed. The discussion is poor.

In addition, the authors should have read the Journal's requirements before submit the paper.

Author Response

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Author Response File: Author Response.pdf

Reviewer 3 Report

It would be nice to :

State if the clinical characteristics of slow and rapid responders differ.

State if a low dose of systemic steroid has been given and if it did influence the viral load.

Discuss on the fact that immunocompetent VZV group have a worse prognosis than immunosuppressed VZV group (?more aggressive treatment ?lower RD occurrence because of lesser vitritis) & on the 0% HSV1 (in comparison to the literature).

Author Response

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Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

It has to be recognized the critical effort made by the authors to improve the article. However, I still consider that some aspects justify not recommending its publication in the current state.

I agree with the authors that their paper is retrospective, but

a power calculation should have been done if this was a retrospective study.