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Case Report

New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient

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SET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74010 Taranto, Italy
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Department of Pneumology, SG Giuseppe Moscati Hospital, 74010 Taranto, Italy
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Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
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Foundation of Physics Research Center, Celico, 87100 Cosenza, Italy
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Department of Blood Banking, SS. Annunziata, 74100 Taranto, Italy
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School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
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Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
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American Stem Cells Hospital, Ho Chi Minh 70000, Vietnam
*
Authors to whom correspondence should be addressed.
These author contributed equally as co-first authors to this work.
These author contributed equally as co-last authors.
Academic Editor: Shiang-Fu Huang
J. Pers. Med. 2022, 12(1), 85; https://doi.org/10.3390/jpm12010085
Received: 25 November 2021 / Revised: 29 December 2021 / Accepted: 4 January 2022 / Published: 10 January 2022
(This article belongs to the Special Issue New Trends in Precision Medicine)
The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), still remains a severe threat. At the time of writing this paper, the second infectious wave has caused more than 280,000 deaths all over the world. Italy was one of the first countries involved, with more than 200,000 people reported as infected and 30,000 deaths. There are no specific treatments for COVID-19 and the vaccine still remains somehow inconclusive. The world health community is trying to define and share therapeutic protocols in early and advanced clinical stages. However, numbers remain critical with a serious disease rate of 14%, ending with sepsis, acute respiratory distress syndrome (ARDS), multiple organ failure (MOF) and vascular and thromboembolic findings. The mortality rate was estimated within 2–3%, and more than double that for individuals over 65 years old; almost one patient in three dies in the Intensive Care Unit (ICU). Efforts for effective solutions are underway with multiple lines of investigations, and health authorities have reported success treating infected patients with donated plasma from survivors of the illness, the proposed benefit being protective antibodies formed by the survivors. Plasma transfusion, blood and stem cells, either autologous or allograft transplantation, are not novel therapies, and in this short paper, we propose therapeutic autologous plasma and peripheral blood stem cells as a possible treatment for fulminant COVID-19 infection. View Full-Text
Keywords: COVID-19; SARS-CoV-2; arterial blood gas (ABG); laboratory medicine; clinical biochemistry and molecular clinical biology; autologous plasma and peripheral blood stem cells COVID-19; SARS-CoV-2; arterial blood gas (ABG); laboratory medicine; clinical biochemistry and molecular clinical biology; autologous plasma and peripheral blood stem cells
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MDPI and ACS Style

Balzanelli, M.G.; Distratis, P.; Lazzaro, R.; D’Ettorre, E.; Nico, A.; Inchingolo, F.; Dipalma, G.; Tomassone, D.; Serlenga, E.M.; Dalagni, G.; Ballini, A.; Nguyen, K.C.D.; Isacco, C.G. New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient. J. Pers. Med. 2022, 12, 85. https://doi.org/10.3390/jpm12010085

AMA Style

Balzanelli MG, Distratis P, Lazzaro R, D’Ettorre E, Nico A, Inchingolo F, Dipalma G, Tomassone D, Serlenga EM, Dalagni G, Ballini A, Nguyen KCD, Isacco CG. New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient. Journal of Personalized Medicine. 2022; 12(1):85. https://doi.org/10.3390/jpm12010085

Chicago/Turabian Style

Balzanelli, Mario G., Pietro Distratis, Rita Lazzaro, Ernesto D’Ettorre, Andrea Nico, Francesco Inchingolo, Gianna Dipalma, Diego Tomassone, Emilio M. Serlenga, Giancarlo Dalagni, Andrea Ballini, Kieu C.D. Nguyen, and Ciro G. Isacco. 2022. "New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient" Journal of Personalized Medicine 12, no. 1: 85. https://doi.org/10.3390/jpm12010085

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