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Article

Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 Vaccine

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Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan
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College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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Graduate Institute of Biomedical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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Graduate Institute of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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Department of Infectious Diseases, Chang Gung Memorial Hospital, Keelung 204, Taiwan
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Department of Laboratory Medicine, Chang Gung Memorial Hospital, Keelung 204, Taiwan
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Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Panayiotis G. Vlachoyiannopoulos and Paraskevi Katsaounou
J. Pers. Med. 2022, 12(1), 68; https://doi.org/10.3390/jpm12010068
Received: 17 December 2021 / Revised: 3 January 2022 / Accepted: 5 January 2022 / Published: 7 January 2022
Background: Data are lacking regarding predictors of quantification of neutralizing antibodies (nAbs) based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 50% neutralization titer (NT50) after a single dose of COVID-19 vaccine in hemodialysis (HD) patients. Methods: This prospective single-center study enrolled 200 HD patients and 82 healthy subjects to estimate antibodies against the SARS-CoV-2 viral spike protein 1 and receptor-binding domain after a first dose of a COVID-19 vaccine (ChAdOx1 or mRNA-1273), measured by enzyme-linked immunosorbent assay and applied spline-based generalized additive model regression analysis to predict NT50 converted to international units. Results: After the first dose of ChAdOx1, multiple linear regression showed that age (p = 0.011) and cardiothoracic ratio (p = 0.002) were negatively associated with NT50. Older age (OR = 0.958, p = 0.052) and higher cardiothoracic ratio (OR < 0.001, p = 0.037) could predict negative humoral response (NT50 < 35.13 IU/mL). NT50 was lower in HD patients compared with healthy controls receiving ChAdOx1 (10.68 vs. 43.01 IU/m, p < 0.001) or mRNA-1273 (36.39 vs. 262.2 IU/mL, p < 0.001). ChAdOx1 elicited lower GMTs than mRNA-1273 in the HD cohort (10.68 vs. 36.39 IU/mL, p < 0.001) and in healthy controls (43.01 vs. 262.22 IU/mL, p < 0.001). Conclusion: High cardiothoracic ratio and old age could independently predict a decline in nAb titers in an HD cohort vaccinated with a single dose of ChAdOx1. View Full-Text
Keywords: COVID-19 vaccine; neutralizing antibodies; clinical response; hemodialysis; effectiveness COVID-19 vaccine; neutralizing antibodies; clinical response; hemodialysis; effectiveness
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MDPI and ACS Style

Chen, C.-Y.; Liu, K.-T.; Shih, S.-R.; Ye, J.-J.; Chen, Y.-T.; Pan, H.-C.; Hsu, H.-J.; Sun, C.-Y.; Lee, C.-C.; Wu, C.-Y.; Lai, C.-C.; Wu, I.-W. Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 Vaccine. J. Pers. Med. 2022, 12, 68. https://doi.org/10.3390/jpm12010068

AMA Style

Chen C-Y, Liu K-T, Shih S-R, Ye J-J, Chen Y-T, Pan H-C, Hsu H-J, Sun C-Y, Lee C-C, Wu C-Y, Lai C-C, Wu I-W. Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 Vaccine. Journal of Personalized Medicine. 2022; 12(1):68. https://doi.org/10.3390/jpm12010068

Chicago/Turabian Style

Chen, Chun-Yu, Kuan-Ting Liu, Shin-Ru Shih, Jung-Jr Ye, Yih-Ting Chen, Heng-Chih Pan, Heng-Jung Hsu, Chiao-Yin Sun, Chin-Chan Lee, Chun-Ying Wu, Chi-Chun Lai, and I-Wen Wu. 2022. "Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 Vaccine" Journal of Personalized Medicine 12, no. 1: 68. https://doi.org/10.3390/jpm12010068

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