Microbiome Changes in Humans with Parkinson’s Disease after Photobiomodulation Therapy: A Retrospective Study
Round 1
Reviewer 1 Report
Please see attached file:
Review_Microbiome in PD after PBM_jpm-1510531.pdf
Comments for author File: 
Comments.pdf
Author Response
We thank the reviewer very much for their comments.
Thank you for pointing out the omission of the full meaning of F:B ratio. This has been corrected in both the Abstract and the Introduction.
The typographical and grammatical errors have been corrected
Once again, thank you for taking the time to review this manuscript and for your very positive comments! comments
Reviewer 2 Report
I have read with great interest the paper submitted by Bicknell et al. entitled "Microbiome changes in humans with Parkinson’s disease after 2
photobiomodulation therapy: a retrospective study".
1. Introduction: the authors should cite these two recent papers (DOI: https://doi.org/10.1152/ajpgi.00161.2019) and GM-ENS interaction (DOI: https://doi.org/10.3390/jcm9113705 ).
2. Materials and Methods: in table 1 the authors should report the day of sample collecting before and after PBM for each patient. Was any questionnaire administered to the patients to assess their diet before/after - despite the fact that patients did not change their dietary behaviours, was it standardized in any manner?
Discussion: the authors does not sufficiently highlights the study limitations but only interpret results.
Author Response
We thank the reviewer very much for their comments.
1. We have included these two references in the Introduction, as well as 3 others i order to give the new references context.
2. The date of sample collection have been added to Table 1. There was no questionnaire or other instrument used to monitor diet. Participants were only asked if their diet had markedly changed over the 12-week period. No participant indicated a change. Any future study would monitor dietary changes more closely.
3. Thank you for this observation. An additional section has been added to the conclusion.
Once again, thank you for taking the time to review this manuscript and for your thoughtful comments
