Next Article in Journal
Maintenance of Maternal Breastfeeding up to 6 Months: Predictive Models
Next Article in Special Issue
Implementation of Pharmacogenomics and Artificial Intelligence Tools for Chronic Disease Management in Primary Care Setting
Previous Article in Journal
Immune Check-Point Inhibitors and Standard Chemoradiotherapy in Definitive Head and Neck Cancer Treatment
Previous Article in Special Issue
Effects of CYP3A5 Polymorphism on Rapid Progression of Chronic Kidney Disease: A Prospective, Multicentre Study
Article

Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children’s Hospital

1
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
2
Arkansas Children’s Research Institute, Little Rock, AR 72202, USA
3
Pediatrics and Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
4
Departments of Pathology and Laboratory Medicine, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR 72202, USA
5
Informatics, Arkansas Children’s Hospital, 1 Children’s Way #512-10, Little Rock, AR 72202, USA
6
Pediatric Hematology/Oncology, Arkansas Children’s Hospital, 1 Children’s Way #512-10, Little Rock, AR 72202, USA
7
Pediatric Neurology, Arkansas Children’s Hospital, 1 Children’s Way, Little Rock, AR 72202, USA
8
Pediatric Cardiology, Arkansas Children’s Hospital, Little Rock, AR 72202, USA
9
Section of Genetics and Metabolism, Arkansas Children’s Hospital, Little Rock, AR 72202, USA
10
Psychiatry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
11
Translational Software, Inc., TSI, Bellevue, WA 98005, USA
12
Arkansas Children’s Hospital NW, Springdale, AR 72762, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Laura B. Scheinfeldt
J. Pers. Med. 2021, 11(5), 394; https://doi.org/10.3390/jpm11050394
Received: 31 March 2021 / Revised: 3 May 2021 / Accepted: 6 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Pharmacogenomics: From Basic Research to Clinical Implementation)
Pharmacogenomics (PGx) is a growing field within precision medicine. Testing can help predict adverse events and sub-therapeutic response risks of certain medications. To date, the US FDA lists over 280 drugs which provide biomarker-based dosing guidance for adults and children. At Arkansas Children’s Hospital (ACH), a clinical PGx laboratory-based test was developed and implemented to provide guidance on 66 pediatric medications for genotype-guided dosing. This PGx test consists of 174 single nucleotide polymorphisms (SNPs) targeting 23 clinically actionable PGx genes or gene variants. Individual genotypes are processed to provide per-gene discrete results in star-allele and phenotype format. These results are then integrated into EPIC- EHR. Genomic indicators built into EPIC-EHR provide the source for clinical decision support (CDS) for clinicians, providing genotype-guided dosing. View Full-Text
Keywords: pharmacogenomics (PGx); pediatrics; best practice alerts (BPAs); electronic health records (EHR); genomic indicators; clinical decision support (CDS); phenotype; genotype pharmacogenomics (PGx); pediatrics; best practice alerts (BPAs); electronic health records (EHR); genomic indicators; clinical decision support (CDS); phenotype; genotype
Show Figures

Figure 1

MDPI and ACS Style

Gill, P.S.; Yu, F.B.; Porter-Gill, P.A.; Boyanton, B.L.; Allen, J.C.; Farrar, J.E.; Veerapandiyan, A.; Prodhan, P.; Bielamowicz, K.J.; Sellars, E.; Burrow, A.; Kennedy, J.L.; Clothier, J.L.; Becton, D.L.; Rule, D.; Schaefer, G.B. Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children’s Hospital. J. Pers. Med. 2021, 11, 394. https://doi.org/10.3390/jpm11050394

AMA Style

Gill PS, Yu FB, Porter-Gill PA, Boyanton BL, Allen JC, Farrar JE, Veerapandiyan A, Prodhan P, Bielamowicz KJ, Sellars E, Burrow A, Kennedy JL, Clothier JL, Becton DL, Rule D, Schaefer GB. Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children’s Hospital. Journal of Personalized Medicine. 2021; 11(5):394. https://doi.org/10.3390/jpm11050394

Chicago/Turabian Style

Gill, Pritmohinder S., Feliciano B. Yu, Patricia A. Porter-Gill, Bobby L. Boyanton, Judy C. Allen, Jason E. Farrar, Aravindhan Veerapandiyan, Parthak Prodhan, Kevin J. Bielamowicz, Elizabeth Sellars, Andrew Burrow, Joshua L. Kennedy, Jeffery L. Clothier, David L. Becton, Don Rule, and G. B. Schaefer 2021. "Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children’s Hospital" Journal of Personalized Medicine 11, no. 5: 394. https://doi.org/10.3390/jpm11050394

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop