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Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
Article

Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype

1
Neuroepidemiology Unit, Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC 3010, Australia
2
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, Australia
3
Accelerated Cure Project for Multiple Sclerosis, Waltham, MA 02451, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Cristina M. Ramo-Tello
J. Pers. Med. 2021, 11(11), 1218; https://doi.org/10.3390/jpm11111218
Received: 4 October 2021 / Revised: 29 October 2021 / Accepted: 15 November 2021 / Published: 17 November 2021
(This article belongs to the Special Issue Personalized Diagnosis and Therapy for Multiple Sclerosis)
Multiple sclerosis (MS), a neuroinflammatory disorder, occurs as non-progressive or progressive phenotypes; both forms present with diverse symptoms that may reduce quality of life (QoL). Adherence to healthy lifestyle behaviors has been associated with higher QoL in people with MS; whether these associations differ based on MS phenotype is unknown. Cross-sectional self-reported observational data from 1108 iConquerMS participants were analysed. Associations between lifestyle behaviors and QoL were assessed by linear regression, and phenotype differences via moderation analyses. Diet, wellness, and physical activity, but not vitamin D or omega-3 supplement use, were associated with QoL. Specifically, certain diet types were negatively associated with QoL in relapsing-remitting MS (RRMS), and positively associated in progressive MS (ProgMS). Participation in wellness activities had mixed associations with QoL in RRMS but was not associated in ProgMS. Physical activity was positively associated with QoL in RRMS and ProgMS. Phenotype differences were observed in diet and wellness with physical QoL, and physical activity with most QoL subdomains. Our findings show lifestyle behaviors are associated with QoL and appear to differ based on MS phenotype. Future studies assessing timing, duration, and adherence of adopting lifestyle behaviors may better inform their role in MS management. View Full-Text
Keywords: multiple sclerosis; lifestyle behavior; MS management; MS phenotype; quality of life multiple sclerosis; lifestyle behavior; MS management; MS phenotype; quality of life
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MDPI and ACS Style

Nag, N.; Yu, M.; Jelinek, G.A.; Simpson-Yap, S.; Neate, S.L.; Schmidt, H.K. Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype. J. Pers. Med. 2021, 11, 1218. https://doi.org/10.3390/jpm11111218

AMA Style

Nag N, Yu M, Jelinek GA, Simpson-Yap S, Neate SL, Schmidt HK. Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype. Journal of Personalized Medicine. 2021; 11(11):1218. https://doi.org/10.3390/jpm11111218

Chicago/Turabian Style

Nag, Nupur, Maggie Yu, George A. Jelinek, Steve Simpson-Yap, Sandra L. Neate, and Hollie K. Schmidt. 2021. "Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype" Journal of Personalized Medicine 11, no. 11: 1218. https://doi.org/10.3390/jpm11111218

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