Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine
Abstract
:1. Introduction
2. Diabetic Eye Disease: Diabetic Retinopathy and Diabetic Macular Edema
2.1. Structural Biomarkers: Optical Coherence Tomography (OCT)
2.1.1. Characterizing Disease Burden and Functional Significance
2.1.2. Imaging Biomarkers and Disease Pathway Expression
2.1.3. Predicting Future Treatment Need and Treatment Response Characteristics
2.2. Vascular Biomarkers: Ultra-Widefield Fluorescein Angiography (UWFA)
2.2.1. Biomarkers for Disease Severity and Disease Burden
2.2.2. Evaluating and Predicting Treatment Response Characteristics
2.2.3. Imaging Biomarkers and Disease Pathway Expression
2.2.4. Radiomics Angiographic Biomarkers for DR Severity
2.2.5. Angiographic Biomarkers for DME Presence
2.2.6. Evaluating and Predicting Therapeutic Response: From Quantitative UWFA to Radiomics
2.3. Vascular Biomarkers: OCTA
Biomarkers for Disease Severity and Burden: From Quantitative Features to Radiomics
3. Age-Related Macular Degeneration (AMD): Neovascular and Non-Neovascular AMD
3.1. Structural Biomarkers: Optical Coherence Tomography (OCT)
3.1.1. Features for Predicting Progression in AMD
3.1.2. Deep Learning and Radiomics Biomarkers in AMD
3.2. Vascular Biomarkers: OCTA
3.2.1. Quantitative Biomarkers of CNV Features
3.2.2. Choriocapillaris Biomarkers in Non-Neovascular AMD
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Kalra, G.; Kar, S.S.; Sevgi, D.D.; Madabhushi, A.; Srivastava, S.K.; Ehlers, J.P. Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine. J. Pers. Med. 2021, 11, 1161. https://doi.org/10.3390/jpm11111161
Kalra G, Kar SS, Sevgi DD, Madabhushi A, Srivastava SK, Ehlers JP. Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine. Journal of Personalized Medicine. 2021; 11(11):1161. https://doi.org/10.3390/jpm11111161
Chicago/Turabian StyleKalra, Gagan, Sudeshna Sil Kar, Duriye Damla Sevgi, Anant Madabhushi, Sunil K. Srivastava, and Justis P. Ehlers. 2021. "Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine" Journal of Personalized Medicine 11, no. 11: 1161. https://doi.org/10.3390/jpm11111161