Is Prevention of Postoperative Vomiting Surgery Dependent? A Retrospective Cohort Study of Total Knee Arthroplasty
Abstract
1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Features | N (%)/Median (IQR) (N = 665) | None-POV (N = 578) | POV (N = 87) | p Value |
---|---|---|---|---|
Sex | ||||
Male | 178 (26.8%) | 167 (28.9%) | 11 (12.6%) | 0.001 |
Female | 487 (73.2%) | 411 (71.1%) | 76 (87.4%) | |
Age (years) | 70 (65–75) | 70 (65–75) | 71 (65–76) | 0.731 |
Weight (kg) | 67 (59–76) | 68 (60–77) | 62 (55–70) | <0.001 |
ACB Block | ||||
None | 287 (43.2%) | 243 (42.0%) | 44 (50.6%) | 0.167 |
Pre-operative | 226 (34.0%) | 204 (35.3%) | 22 (25.3%) | |
Post-operative | 152 (22.9%) | 131 (22.7%) | 21 (24.1%) | |
ASA | ||||
II | 408 (61.4%) | 351 (60.7%) | 57 (65.5%) | 0.422 |
III | 257 (38.6%) | 227 (39.3%) | 30 (34.5%) | |
Anesthesia time (h) | 3.17 (2.83–3.50) | 3.18 (2.85–3.50) | 3.07 (2.75–3.45) | 0.071 |
Apfel Score | ||||
0 | 56 (8.4%) | 51 (8.8%) | 5 (5.7%) | 0.570 |
1 | 154 (23.2%) | 137 (23.7%) | 17 (19.5%) | |
2 | 311 (46.8%) | 267 (46.2%) | 44 (50.6%) | |
≥3 | 144 (21.7%) | 123 (21.3%) | 21 (24.1%) | |
Charlson Comorbidity Index | ||||
0 | 173 (26.0%) | 152 (26.3%) | 21 (24.1%) | 0.410 |
1 | 282 (42.4%) | 247 (42.7%) | 35 (40.2%) | |
2 | 138 (20.8%) | 121 (20.9%) | 17 (19.5%) | |
≥3 | 72 (10.8%) | 58 (10.0%) | 14 (16.1%) |
Variables (Unit) | N (%)/ | Univariate | Multivariable | ||
---|---|---|---|---|---|
Median (IQR) | OR (95% CI) | p-Value | OR (95% CI) | p Value | |
Sex-Male | 178 (26.8%) | 1 | 1 | ||
Sex-Female | 487 (73.2%) | 2.81 (1.46–5.42) | 0.002 | 2.49 (1.19–5.20) | 0.015 |
Age- | 70 (65–75) | 1.01 (0.98–1.04) | 0.706 | 1.00 (0.97–1.03) | 0.977 |
ACB Block-None | 287 (43.2%) | 1 | 1 | ||
Nerve Block-Pre-op | 226 (34.0%) | 0.60 (0.35–1.03) | 0.062 | 0.48 (0.26–0.87) | 0.016 |
Nerve Block-Post-op | 152 (22.9%) | 0.89 (0.51–1.55) | 0.671 | 0.66 (0.36–1.22) | 0.188 |
Weight (kg) | 67 (59–76) | 0.97 (0.95–0.99) | 0.001 | 0.98 (0.95–1.00) | 0.065 |
ASA II | 408 (61.4%) | 1 | 1 | ||
ASA III | 257 (38.6%) | 0.81 (0.51–1.31) | 0.393 | 0.74 (0.44–1.24) | 0.252 |
Apfel Score 0 | 56 (8.4%) | 1 | 1 | ||
Apfel Score 1 | 154 (23.2%) | 1.27 (0.44–3.61) | 0.659 | 1.72 (0.56–5.27) | 0.344 |
Apfel Score 2 | 311 (46.8%) | 1.68 (0.64–4.44) | 0.295 | 1.68 (0.58–4.80) | 0.337 |
Apfel Score 3&4 | 144 (21.7%) | 1.74 (0.62–4.87) | 0.290 | 2.19 (0.70–6.85) | 0.180 |
Duration (h) | 3.17 (2.83–3.50) | 0.69 (0.45–1.05) | 0.081 | 0.70 (0.44–1.11) | 0.133 |
Sevoflurane consumption (mL/h) | 0.20 (0.17–0.25) | 55.04 (1.50–2019.69) | 0.029 | 2.84 (0.04–201.49) | 0.631 |
Crystalloid (mL/h/kg) | 2.51 (2.04–3.28) | 0.96 (0.76–1.21) | 0.734 | 0.82 (0.61–1.11) | 0.199 |
Intraoperative Urine (mL/h/kg) | 1.00 (0.00–2.02) | 0.89 (0.74–1.08) | 0.224 | 0.87 (0.70–1.07) | 0.172 |
PCA-none | 616 (92.6%) | 1 | 1 | ||
PCA-Yes | 49 (7.4%) | 0.57 (0.20–1.63) | 0.295 | 0.73 (0.21–2.57) | 0.624 |
Kinds of anti-emetics-none | 296 (44.5%) | 1 | 1 | ||
One | 333 (50.1%) | 0.66 (0.42–1.05) | 0.081 | 0.57 (0.34–0.94) | 0.028 |
Two | 36 (5.4%) | 0.48 (0.14–1.64) | 0.241 | 0.40 (0.09–1.75) | 0.224 |
Kinds of anti-hypertension-none | 223 (33.5%) | 1 | 1 | ||
One | 349 (52.5%) | 1.00 (0.61–1.64) | 0.996 | 0.94 (0.55–1.61) | 0.823 |
Two | 93 (14.0%) | 0.78 (0.36–1.66) | 0.511 | 0.72 (0.32–1.63) | 0.424 |
Intraoperative MME (mg/kg) | 0.23 (0.18–0.29) | 10.83 (1.51–77.69) | 0.018 | 7.04 (0.73–68.03) | 0.092 |
MME at PACU (mg/kg) | 0.02 (0.01–0.02) | 0.62 (0.00–1157.62) | 0.901 | 2.03 (0.00–5332.59) | 0.860 |
MME at Ward (mg/kg) | 0.10 (0.09–0.11) | 0.44 (0.07–2.75) | 0.377 | 0.59 (0.08–4.38) | 0.607 |
Variables (Unit) | N (%)/ | Multivariable | |
---|---|---|---|
Median (IQR) | OR (95% CI) | p Value | |
Sex-Male | 178 (26.8%) | 1 | |
Sex-Female | 487 (73.2%) | 2.58(1.29–5.14) | 0.007 |
ACB Block-None | 287 (43.2%) | 1 | |
Nerve Block-Pre-op | 226 (34.0%) | 0.53(0.30–0.93) | 0.028 |
Nerve Block-Post-op | 152 (22.9%) | 0.71(0.39–1.28) | 0.251 |
Weight (kg) | 67 (59–76) | 0.98(0.96–1.00) | 0.046 |
Duration (h) | 3.17 (2.83–3.50) | 0.70(0.45–1.09) | 0.110 |
Intraoperative Urine (mL/h/kg) | 1.00 (0.00–2.02) | 0.83(0.68–1.01) | 0.059 |
Kinds of anti-emetics-none | 296 (44.5%) | 1 | |
One | 333 (50.1%) | 0.62(0.38–1.01) | 0.054 |
Two | 36 (5.4%) | 0.38(0.11–1.35) | 0.134 |
Intraoperative MME (mg/kg) | 0.23 (0.18–0.29) | 6.28(0.89–44.53) | 0.066 |
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Poon, Y.-Y.; Hung, K.-C.; Chou, W.-Y.; Wang, C.-H.; Hung, C.-T.; Chin, J.-C.; Wu, S.-C. Is Prevention of Postoperative Vomiting Surgery Dependent? A Retrospective Cohort Study of Total Knee Arthroplasty. J. Pers. Med. 2021, 11, 1018. https://doi.org/10.3390/jpm11101018
Poon Y-Y, Hung K-C, Chou W-Y, Wang C-H, Hung C-T, Chin J-C, Wu S-C. Is Prevention of Postoperative Vomiting Surgery Dependent? A Retrospective Cohort Study of Total Knee Arthroplasty. Journal of Personalized Medicine. 2021; 11(10):1018. https://doi.org/10.3390/jpm11101018
Chicago/Turabian StylePoon, Yan-Yuen, Kuo-Chuan Hung, Wen-Yi Chou, Chih-Hsien Wang, Chao-Ting Hung, Jo-Chi Chin, and Shao-Chun Wu. 2021. "Is Prevention of Postoperative Vomiting Surgery Dependent? A Retrospective Cohort Study of Total Knee Arthroplasty" Journal of Personalized Medicine 11, no. 10: 1018. https://doi.org/10.3390/jpm11101018
APA StylePoon, Y.-Y., Hung, K.-C., Chou, W.-Y., Wang, C.-H., Hung, C.-T., Chin, J.-C., & Wu, S.-C. (2021). Is Prevention of Postoperative Vomiting Surgery Dependent? A Retrospective Cohort Study of Total Knee Arthroplasty. Journal of Personalized Medicine, 11(10), 1018. https://doi.org/10.3390/jpm11101018