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Article

Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors

by 1, 1,2, 3, 3 and 1,3,*
1
MTA-DE Public Health Research Group, University of Debrecen, 4028 Debrecen, Hungary
2
Doctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary
3
Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2021, 11(1), 6; https://doi.org/10.3390/jpm11010006
Received: 13 November 2020 / Revised: 17 December 2020 / Accepted: 20 December 2020 / Published: 22 December 2020
(This article belongs to the Section Omics/Informatics)
It is generally accepted that the early detection of type 2 diabetes mellitus (T2DM) is important to prevent the development of complications and comorbidities, as well as premature death. The onset of type 2 diabetes mellitus results from a complex interplay between genetic, environmental, and lifestyle risk factors. Our study aims to evaluate the joint effect of T2DM associated single nucleotide polymorphisms (SNPs) on the age of onset for T2DM in combination with conventional risk factors (such as sex, body mass index (BMI), and TG/HDL-C ratio) in the Hungarian population. This study includes 881 T2DM patients (Case population) and 1415 samples from the Hungarian general population (HG). Twenty-three SNPs were tested on how they are associated with the age of onset for T2DM in the Case population and 12 of them with a certified effect on the age of T2DM onset were chosen for an optimized genetic risk score (GRS) analysis. Testing the validity of the GRS model developed was carried out on the HG population. The GRS showed a significant association with the age of onset for T2DM (β = −0.454, p = 0.001) in the Case population, as well as among T2DM patients in the HG one (β = −0.999, p = 0.003) in the replication study. The higher the GRS, the earlier was the T2DM onset. Individuals with more than eight risk alleles will presumably be diabetic six and a half years earlier than those with less than four risk alleles. Our results suggest that there is a considerable genetic predisposition for the early onset of T2DM; therefore, in addition to conventional risk factors, GRS can be used as a tool for estimating the risk of the earlier onset of T2DM and stratifying populations at risk in order to define preventive interventions. View Full-Text
Keywords: age of onset for type 2 diabetes; single nucleotide polymorphism; genetic risk score; type 2 diabetes mellitus; Hungarian population age of onset for type 2 diabetes; single nucleotide polymorphism; genetic risk score; type 2 diabetes mellitus; Hungarian population
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MDPI and ACS Style

Piko, P.; Werissa, N.A.; Fiatal, S.; Sandor, J.; Adany, R. Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors. J. Pers. Med. 2021, 11, 6. https://doi.org/10.3390/jpm11010006

AMA Style

Piko P, Werissa NA, Fiatal S, Sandor J, Adany R. Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors. Journal of Personalized Medicine. 2021; 11(1):6. https://doi.org/10.3390/jpm11010006

Chicago/Turabian Style

Piko, Peter, Nardos A. Werissa, Szilvia Fiatal, Janos Sandor, and Roza Adany. 2021. "Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors" Journal of Personalized Medicine 11, no. 1: 6. https://doi.org/10.3390/jpm11010006

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