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Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting?

1
Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
2
Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to the work.
J. Pers. Med. 2020, 10(4), 227; https://doi.org/10.3390/jpm10040227
Received: 15 September 2020 / Revised: 20 October 2020 / Accepted: 11 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Innovations in the Integrated Management of Breast Cancer)
Although they cannot be considered curative, the new therapeutic integrated advances in metastatic breast cancer (MBC) have substantially improved patient outcomes. Traditionally, surgery was confined to palliation of symptomatic or ulcerating lumps. Data suggest, in some cases, a possible additive role for more aggressive locoregional surgical therapy in combination with systemic treatments in the metastatic setting, although a low level of evidence has been shown in terms of improvement in overall survival in MBC patients treated with surgery and medical treatment compared to medical treatment alone. In this light, tumor heterogeneity remains a challenge. To effectively reshape the therapeutic approach to MBC, careful consideration of who is a good candidate for locoregional resection is paramount. The patient’s global health condition, impacting on cancer progression and morbidity and their associated molecular targets, have to be considered in treatment decision-making. In particular, more recently, research has been focused on the role of metabolic derangements, including the presence of metabolic syndrome, which represent well-known conditions related to breast cancer recurrence and distant metastasis and are, therefore, involved in the prognosis. In the present article, we focus on locoregional surgical strategies in MBC and whether concomitant metabolic derangements may have a role in prognosis. View Full-Text
Keywords: metastatic breast cancer; breast surgery; immune system; metabolic derangements; precision medicine; integrated therapies metastatic breast cancer; breast surgery; immune system; metabolic derangements; precision medicine; integrated therapies
MDPI and ACS Style

Amabile, M.I.; Frusone, F.; De Luca, A.; Tripodi, D.; Imbimbo, G.; Lai, S.; D’Andrea, V.; Sorrenti, S.; Molfino, A. Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting? J. Pers. Med. 2020, 10, 227. https://doi.org/10.3390/jpm10040227

AMA Style

Amabile MI, Frusone F, De Luca A, Tripodi D, Imbimbo G, Lai S, D’Andrea V, Sorrenti S, Molfino A. Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting? Journal of Personalized Medicine. 2020; 10(4):227. https://doi.org/10.3390/jpm10040227

Chicago/Turabian Style

Amabile, Maria I.; Frusone, Federico; De Luca, Alessandro; Tripodi, Domenico; Imbimbo, Giovanni; Lai, Silvia; D’Andrea, Vito; Sorrenti, Salvatore; Molfino, Alessio. 2020. "Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting?" J. Pers. Med. 10, no. 4: 227. https://doi.org/10.3390/jpm10040227

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