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Article

Radiation Biomarkers in Large Scale Human Health Effects Studies

1
Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UK
2
Department of Radiotherapy & Radio-Oncology, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(4), 155; https://doi.org/10.3390/jpm10040155
Received: 3 September 2020 / Revised: 28 September 2020 / Accepted: 1 October 2020 / Published: 3 October 2020
(This article belongs to the Special Issue Radiation Response Biomarkers for Individualised Cancer Treatments)
Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward. View Full-Text
Keywords: ionizing radiation; biomarkers; dicentric assay; micronucleus assay; gamma H2AX foci assay; health surveillance analyses ionizing radiation; biomarkers; dicentric assay; micronucleus assay; gamma H2AX foci assay; health surveillance analyses
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MDPI and ACS Style

Moquet, J.; Rothkamm, K.; Barnard, S.; Ainsbury, E. Radiation Biomarkers in Large Scale Human Health Effects Studies. J. Pers. Med. 2020, 10, 155. https://doi.org/10.3390/jpm10040155

AMA Style

Moquet J, Rothkamm K, Barnard S, Ainsbury E. Radiation Biomarkers in Large Scale Human Health Effects Studies. Journal of Personalized Medicine. 2020; 10(4):155. https://doi.org/10.3390/jpm10040155

Chicago/Turabian Style

Moquet, Jayne, Kai Rothkamm, Stephen Barnard, and Elizabeth Ainsbury. 2020. "Radiation Biomarkers in Large Scale Human Health Effects Studies" Journal of Personalized Medicine 10, no. 4: 155. https://doi.org/10.3390/jpm10040155

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