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Acquisition of Quasi-Monochromatic Dual-Energy in a Microfocus X-ray Generator and Development of Applied Technology

1
Department of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo 113-8655, Japan
2
Department of Radiological Sciences, Faculty of Health Sciences, Komazawa University, Setagaya-ku, Tokyo 154-8525, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(1), 27; https://doi.org/10.3390/diagnostics9010027
Received: 31 January 2019 / Revised: 27 February 2019 / Accepted: 27 February 2019 / Published: 4 March 2019
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Abstract

In regenerative medicine, evaluation of bone mineral density using a microfocus X-ray generator could eventually be used to determine the degree of bone tissue regeneration. To evaluate bone mineral density against regenerated bone material, two low-energy X-rays are necessary. Herein, the acquisition of quasi-monochromatic, dual-energy soft X-ray and the subsequent medical application were examined using the K-absorption edges of two types of metal filters (i.e., zirconium and tin) in a microfocus X-ray generator. Investigation of the optimal tube voltage and filter thickness to form a quasi-monochromatic energy spectrum with a single filter revealed that a filter thickness of 0.3 mm results in an optimal monochromatization state. When a dual filter was used, the required filter thickness was 0.3 mm for tin and 0.2 mm for zirconium at a tube voltage of 35 kV. For the medical application, we measured quasi-monochromatic, dual-energy X-rays to evaluate the measurement accuracy of bone mineral density. Using aluminum as a simulated bone sample, a relative error of ≤5% was consistent within the aluminum thickness range of 1–3 mm. These data suggest that a bone mineral density indicator of recycled bone material can be easily obtained with the quasi-monochromatic X-ray technique using a microfocus X-ray generator. View Full-Text
Keywords: microfocus X-ray generator; DEXA; K-absorption edge; dual-energy X-ray; bone mineral density microfocus X-ray generator; DEXA; K-absorption edge; dual-energy X-ray; bone mineral density
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Hasegawa, H.; Sato, M. Acquisition of Quasi-Monochromatic Dual-Energy in a Microfocus X-ray Generator and Development of Applied Technology. Diagnostics 2019, 9, 27.

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