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Open AccessReview

Recent Progress in the Development of Diagnostic Tests for Malaria

1
West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, Ghana
2
Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana
3
Nanotechnology & Integrated Bioengineering Centre, Ulster University, Jordanstown BT37 0QB, UK
*
Author to whom correspondence should be addressed.
Diagnostics 2017, 7(3), 54; https://doi.org/10.3390/diagnostics7030054
Received: 27 August 2017 / Revised: 13 September 2017 / Accepted: 14 September 2017 / Published: 19 September 2017
The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains. However, the widely utilized Giemsa-stained microscopy and immunochromatographic tests for malaria are liable to several drawbacks, including inadequate sensitivity and false-positive outcomes. Alternative methods that offer improvements in performance are either expensive, have longer turnaround time or require a level of expertise that makes them unsuitable for point-of-care (POC) applications. These gaps necessitate exploration of more efficient detection techniques with the potential of POC applications, especially in resource-limited settings. This minireview discusses some of the recent trends and new approaches that are seeking to improve the clinical diagnosis of malaria. View Full-Text
Keywords: rapid diagnostic tests (RDT); biosensing; lateral flow assays; Plasmodium spp.; multiplex biomarker detection; histidine-rich protein 2 (HRP2); lactate dehydrogenase (LDH); aldolase; point-of-care tests (POCT); disposal medical devices; infectious diseases rapid diagnostic tests (RDT); biosensing; lateral flow assays; Plasmodium spp.; multiplex biomarker detection; histidine-rich protein 2 (HRP2); lactate dehydrogenase (LDH); aldolase; point-of-care tests (POCT); disposal medical devices; infectious diseases
MDPI and ACS Style

Krampa, F.D.; Aniweh, Y.; Awandare, G.A.; Kanyong, P. Recent Progress in the Development of Diagnostic Tests for Malaria. Diagnostics 2017, 7, 54.

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