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In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

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Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
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Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark
3
Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark
4
GE Healthcare, Brøndby 2605, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Graham Jackson
Diagnostics 2015, 5(3), 287-289; https://doi.org/10.3390/diagnostics5030287
Received: 13 May 2015 / Revised: 17 June 2015 / Accepted: 19 June 2015 / Published: 26 June 2015
(This article belongs to the Collection Hybrid Imaging in Medicine)
In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that 18F-FDG-PET may not always reflect the Warburg effect in all tumors. View Full-Text
Keywords: cancer; dynamic nuclear polarization; hyperpolarized; 13C-pyruvate; MR; 18F-FDG-PET; PET/MR; molecular imaging; hyperPET cancer; dynamic nuclear polarization; hyperpolarized; 13C-pyruvate; MR; 18F-FDG-PET; PET/MR; molecular imaging; hyperPET
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Gutte, H.; Hansen, A.E.; Larsen, M.M.; Rahbek, S.; Johannesen, H.H.; Ardenkjaer-Larsen, J.; Kristensen, A.T.; Højgaard, L.; Kjaer, A. In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect. Diagnostics 2015, 5, 287-289.

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