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Unveiling Hidden Abscesses: The Clinical Utility of Diffusion-Weighted Whole-Body Imaging with Background Suppression (DWIBS) in Metastatic Abscess Screening
 
 
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Diagnostics
Volume 16
Issue 2
10.3390/diagnostics16020225
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Article

Diffusion-Weighted Whole-Body Magnetic Resonance Imaging with Background Body Signal Suppression for Differentiating Infectious from Non-Infectious Aortitis

by
Jien Saito
1,2,3,*,
Masahiro Muto
4,
Masafumi Tada
5,6,
Isao Yokota
3,
Shinji Kamiya
2,
Yukihide Numata
2,
Hideki Sasaki
2,
Takuya Hashizume
7,
Kenji Iwata
7,
Miki Asano
2 and
Satoru Wakasa
1
1
Department of Cardiovascular Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan
2
Department of Cardiovascular Surgery, Nagoya City University East Medical Center, Nagoya, Aichi 464-8547, Japan
3
Department of Biostatistics, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
4
Department of Radiology, Ogaki Municipal Hospital, Ogaki, Gifu 503-8502, Japan
5
Department of Health Promotion and Human Behavior, School of Public Health, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8501, Japan
6
Department of Neurology, Nagoya City University East Medical Center, Nagoya, Aichi 464-8547, Japan
7
Department of Radiology, Nagoya City University East Medical Center, Nagoya , Aichi 464-8547, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2026, 16(2), 225; https://doi.org/10.3390/diagnostics16020225 (registering DOI)
Submission received: 25 November 2025 / Revised: 31 December 2025 / Accepted: 7 January 2026 / Published: 10 January 2026
(This article belongs to the Section Medical Imaging and Theranostics)
Review Reports Versions Notes

Abstract

Background/Objectives: This study examined the clinical utility of diffusion-weighted whole-body magnetic resonance imaging with background body signal suppression (DWIBS) for differentiating infectious from non-infectious aortitis. Methods: The study included 32 patients with suspected inflammatory aortitis who underwent non-contrast computed tomography (NCCT) and magnetic resonance imaging. We evaluated the diagnostic performance of DWIBS using the spinal cord as a reference, NCCT, and their combination. The diagnosis of infectious aortitis was adjudicated based on imaging, clinical, and laboratory findings. We conducted a sensitivity analysis using a stricter definition of infectious aortitis that required both surgical and microbiological confirmation. Results: Fifteen patients were diagnosed with infectious aortitis. The sensitivity, specificity, and areas under the receiver operating characteristic curves were 93.3%, 70.6%, and 0.82, respectively, for NCCT; 93.3%, 76.5%, and 0.85, respectively, for DWIBS; and 86.7%, 94.1%, and 0.90, respectively, for the combination of both modalities. In the sensitivity analysis, the combined DWIBS and NCCT approach demonstrated a specificity of 87.5% and a sensitivity of 70.8%. Conclusions: DWIBS using the spinal cord as a reference appears to be a promising diagnostic tool for differentiating infectious from non-infectious aortitis, especially when combined with NCCT.
Keywords: whole-body imaging; aortitis; communicable diseases; diffusion magnetic resonance imaging; computed tomography whole-body imaging; aortitis; communicable diseases; diffusion magnetic resonance imaging; computed tomography

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MDPI and ACS Style

Saito, J.; Muto, M.; Tada, M.; Yokota, I.; Kamiya, S.; Numata, Y.; Sasaki, H.; Hashizume, T.; Iwata, K.; Asano, M.; et al. Diffusion-Weighted Whole-Body Magnetic Resonance Imaging with Background Body Signal Suppression for Differentiating Infectious from Non-Infectious Aortitis. Diagnostics 2026, 16, 225. https://doi.org/10.3390/diagnostics16020225

AMA Style

Saito J, Muto M, Tada M, Yokota I, Kamiya S, Numata Y, Sasaki H, Hashizume T, Iwata K, Asano M, et al. Diffusion-Weighted Whole-Body Magnetic Resonance Imaging with Background Body Signal Suppression for Differentiating Infectious from Non-Infectious Aortitis. Diagnostics. 2026; 16(2):225. https://doi.org/10.3390/diagnostics16020225

Chicago/Turabian Style

Saito, Jien, Masahiro Muto, Masafumi Tada, Isao Yokota, Shinji Kamiya, Yukihide Numata, Hideki Sasaki, Takuya Hashizume, Kenji Iwata, Miki Asano, and et al. 2026. "Diffusion-Weighted Whole-Body Magnetic Resonance Imaging with Background Body Signal Suppression for Differentiating Infectious from Non-Infectious Aortitis" Diagnostics 16, no. 2: 225. https://doi.org/10.3390/diagnostics16020225

APA Style

Saito, J., Muto, M., Tada, M., Yokota, I., Kamiya, S., Numata, Y., Sasaki, H., Hashizume, T., Iwata, K., Asano, M., & Wakasa, S. (2026). Diffusion-Weighted Whole-Body Magnetic Resonance Imaging with Background Body Signal Suppression for Differentiating Infectious from Non-Infectious Aortitis. Diagnostics, 16(2), 225. https://doi.org/10.3390/diagnostics16020225

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