Gallbladder Schwannoma: A Case Report and Literature Review

Liu, Qinyu; Huang, Runze; Ni, Shujuan; Jin, Xin; Bai, Xuanci; Wang, Lu; Zhu, Weiping

doi:10.3390/diagnostics15222827

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Open AccessCase Report

Gallbladder Schwannoma: A Case Report and Literature Review

by

Qinyu Liu

^1,2,†,

Runze Huang

^1,2,†,

Shujuan Ni

^2,3,†,

Xin Jin

^1,2

,

Xuanci Bai

^1,2,

Lu Wang

^1,2,* and

Weiping Zhu

^1,2,*

¹

Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China

²

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

³

Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Diagnostics 2025, 15(22), 2827; https://doi.org/10.3390/diagnostics15222827 (registering DOI)

Submission received: 9 October 2025 / Revised: 6 November 2025 / Accepted: 6 November 2025 / Published: 7 November 2025

(This article belongs to the Section Pathology and Molecular Diagnostics)

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Abstract

Background and Clinical Significance: Schwannoma is a benign, encapsulated neurogenic neoplasm that originates from Schwann cells of the peripheral nerve sheath. While these tumors may develop in virtually any anatomical location, gallbladder schwannomas are exceptionally rare. Case Presentation: A 56-year-old female patient underwent hepatic tumor resection and cholecystectomy following imaging findings suggestive of possible small hepatocellular carcinoma in the right hepatic lobe and biliary cystadenoma. Postoperative pathological examination confirmed that the liver lesion was a lymphoproliferative disorder and that the gallbladder lesion was a classic schwannoma. The patient recovered well with no evidence of disease recurrence during the two-month follow-up. Conclusions: Current literature indicates that the pathogenesis of gallbladder schwannomas remains unclear, with no apparent age or gender predilection. These lesions lack distinctive clinical or radiological features, necessitating histopathological confirmation. However, they demonstrate excellent prognosis, with no reported recurrence after complete surgical excision.

Keywords: schwannoma; gallbladder mass; pathogenesis; clinical features; treatment

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MDPI and ACS Style

Liu, Q.; Huang, R.; Ni, S.; Jin, X.; Bai, X.; Wang, L.; Zhu, W. Gallbladder Schwannoma: A Case Report and Literature Review. Diagnostics 2025, 15, 2827. https://doi.org/10.3390/diagnostics15222827

AMA Style

Liu Q, Huang R, Ni S, Jin X, Bai X, Wang L, Zhu W. Gallbladder Schwannoma: A Case Report and Literature Review. Diagnostics. 2025; 15(22):2827. https://doi.org/10.3390/diagnostics15222827

Chicago/Turabian Style

Liu, Qinyu, Runze Huang, Shujuan Ni, Xin Jin, Xuanci Bai, Lu Wang, and Weiping Zhu. 2025. "Gallbladder Schwannoma: A Case Report and Literature Review" Diagnostics 15, no. 22: 2827. https://doi.org/10.3390/diagnostics15222827

APA Style

Liu, Q., Huang, R., Ni, S., Jin, X., Bai, X., Wang, L., & Zhu, W. (2025). Gallbladder Schwannoma: A Case Report and Literature Review. Diagnostics, 15(22), 2827. https://doi.org/10.3390/diagnostics15222827

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