Next Article in Journal
Altered Sleep Patterns in Wilson’s Disease Including Shortened REM Latency
Previous Article in Journal
Pediatric Bronchoscopy for the Adult Interventional Pulmonologist
Previous Article in Special Issue
Electrophysiological Evidence of Early Auditory Dysfunction in Personal Listening Device Users: Insights from ABR with Ipsilateral Masking
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 15
Issue 21
10.3390/diagnostics15212770
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Systematic Review

Analysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis

by
Linrui Chen
1,2,3,4,†,
Jianhui Qiu
1,2,3,4,
Qianqian Zhang
2,3,4,5,†,
Zian Xi
6,
Qiong Wu
2,3,4,
Mingwei Xu
2,3,4,
Qin Zhang
2,3,4,
Yulian Jin
2,3,4,
Jun Yang
2,3,4,
Maoli Duan
7,8,*,
Qing Zhang
2,3,4,* and
Zhiyuan Zhang
1,*
1
Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
2
Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
3
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
4
Shanghai Key Laboratory of Translational Medicine in Ear and Nose Diseases, Shanghai 200092, China
5
Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China
6
International Medical School, Chongqing Medical University, Chongqing 400016, China
7
Division of Ear, Nose and Throat Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institute, SE-171 77 Stockholm, Sweden
8
Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2025, 15(21), 2770; https://doi.org/10.3390/diagnostics15212770 (registering DOI)
Submission received: 2 September 2025 / Revised: 25 October 2025 / Accepted: 27 October 2025 / Published: 31 October 2025
(This article belongs to the Special Issue Recent Advances in Hearing and Audiology Science: Diagnosis and Management)
Versions Notes

Abstract

Objectives: Patients with severe to profound sudden sensorineural hearing loss (SSNHL) generally experience poorer hearing recovery; however, the associated risk factors have not been identified. This study synthesizes current evidence to explore prognostic risk factors in this patient group. Methods: Databases were systematically searched through PubMed, Embase, Web of Science, and the Cochrane Library, from their inception to 18 October 2025. Three researchers independently extracted and recorded patient information and relevant data from all selected studies. Any inconsistencies were clarified through discussion or by consulting a fourth researcher. Results: The study included 2632 patients from 15 articles published between 2002 and 2025 and evaluated 8 prognostic risk factors. The results showed that profound hearing loss (OR = 4.68; 95% CI: 3.57–6.13; p < 0.001) and vertigo (OR = 1.95; 95% CI: 1.28–2.98; p = 0.002) were correlated with poorer hearing recovery. Subgroup analyses based on different prognostic criteria confirmed the consistent impact of hearing loss severity on poor outcomes. The remaining 6 risk factors did not show statistically meaningful associations. Conclusions: Profound hearing loss and vertigo are significantly associated with poorer prognosis in patients with severe to profound SSNHL. These findings may help identify high-risk patients early and inform the design of personalized therapeutic approaches in clinical settings.
Keywords: sudden sensorineural hearing loss; meta-analysis; prognosis; severe to profound; risk factors sudden sensorineural hearing loss; meta-analysis; prognosis; severe to profound; risk factors

Share and Cite

MDPI and ACS Style

Chen, L.; Qiu, J.; Zhang, Q.; Xi, Z.; Wu, Q.; Xu, M.; Zhang, Q.; Jin, Y.; Yang, J.; Duan, M.; et al. Analysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis. Diagnostics 2025, 15, 2770. https://doi.org/10.3390/diagnostics15212770

AMA Style

Chen L, Qiu J, Zhang Q, Xi Z, Wu Q, Xu M, Zhang Q, Jin Y, Yang J, Duan M, et al. Analysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis. Diagnostics. 2025; 15(21):2770. https://doi.org/10.3390/diagnostics15212770

Chicago/Turabian Style

Chen, Linrui, Jianhui Qiu, Qianqian Zhang, Zian Xi, Qiong Wu, Mingwei Xu, Qin Zhang, Yulian Jin, Jun Yang, Maoli Duan, and et al. 2025. "Analysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis" Diagnostics 15, no. 21: 2770. https://doi.org/10.3390/diagnostics15212770

APA Style

Chen, L., Qiu, J., Zhang, Q., Xi, Z., Wu, Q., Xu, M., Zhang, Q., Jin, Y., Yang, J., Duan, M., Zhang, Q., & Zhang, Z. (2025). Analysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis. Diagnostics, 15(21), 2770. https://doi.org/10.3390/diagnostics15212770

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop