Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications

Loutati, Ranel; Taha, Louay; Karmi, Mohammad; Fink, Noam; Sabouret, Pierre; A. Mamas, Mamas; Naimark, Ari; Tvito, Ariella; Wiener-Well, Yonit; Abu-Salman, Amjad; Shuvy, Mony; Merin, Ofer; Glikson, Michael; Asher, Elad

doi:10.3390/diagnostics15202563

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Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications

by

Ranel Loutati

¹

,

Louay Taha

¹,

Mohammad Karmi

¹,

Noam Fink

²

,

Pierre Sabouret

^3,4

,

Mamas A. Mamas

⁵,

Ari Naimark

⁶,

Ariella Tvito

¹,

Yonit Wiener-Well

¹,

Amjad Abu-Salman

¹,

Mony Shuvy

¹,

Ofer Merin

⁷,

Michael Glikson

¹ and

Elad Asher

^1,*

¹

Jesselson Integrated Heart Center, The Eisenberg R&D Authority, Shaare Zedek Medical Center, and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel

²

Assuta Medical Centers, Faculty of Medicine, Tel Aviv University, Tel Aviv 6329302, Israel

³

ACTION Study Group, Institut de Cardiologie, Hôpital Pitié-Salpêtrière, Sorbonne Université, 75005 Paris, France

⁴

National College of French Cardiologists, 13 Rue Niepce, 75014 Paris, France

⁵

Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Stoke-on-Trent ST5 5BG, UK

⁶

Department of Cardiothoracic Surgery, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel

⁷

Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem 9103102, Israel

^*

Author to whom correspondence should be addressed.

Diagnostics 2025, 15(20), 2563; https://doi.org/10.3390/diagnostics15202563 (registering DOI)

Submission received: 24 September 2025 / Revised: 5 October 2025 / Accepted: 9 October 2025 / Published: 11 October 2025

(This article belongs to the Special Issue Clinical Diagnosis and Management in Cardiology)

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Abstract

Background: Intensive Cardiovascular Care Units (ICCUs) are critical in managing high-acuity cardiovascular conditions, yet contemporary data on evolving admission patterns and their association with outcomes are limited. Methods: We conducted a retrospective cohort study of all patients admitted to a tertiary-care ICCU between July 2019 and December 2024. Patients were stratified by admission period: early (2019–2021) and late (2022–2024). Baseline characteristics, index diagnosis, interventions, complications, and mortality outcomes were compared. The primary endpoints were in-hospital and one-year mortality. Results: The study included 6266 patients (median age 69 years, 32% female). Of them, 3125 and 3141 patients were admitted in the early and late periods, respectively. Patients in the later period exhibited a higher burden of co-morbidities, including increased rates of atrial fibrillation, cognitive impairment, and dialysis (p < 0.05 for all). The pattern of index diagnoses shifted, showing an increase in heart failure (5.6% vs. 3.7%, p = 0.001) and malignant arrhythmia admissions (13.9% vs. 9.3%, p < 0.001), alongside a decline in cases of NSTEMI and pulmonary embolism. The use of urgent percutaneous coronary intervention, transcatheter valvular interventions, and microaxial pumps increased, whereas intra-aortic balloon pump usage declined. In-hospital mortality remained consistent between the periods at 2.7%. However, adjusted one-year mortality was significantly reduced in the later period (adjusted HR 0.84, 95% CI 0.71–0.98, p = 0.037). Conclusions: Over five years, ICCU admissions showed increasing complexity and evolving procedural trends. Despite higher acuity, adjusted one-year survival improved, highlighting care advances and the value of continuous data-driven ICCU optimization.

Keywords: intensive cardiovascular care unit; admission trends; one-year mortality

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MDPI and ACS Style

Loutati, R.; Taha, L.; Karmi, M.; Fink, N.; Sabouret, P.; A. Mamas, M.; Naimark, A.; Tvito, A.; Wiener-Well, Y.; Abu-Salman, A.; et al. Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications. Diagnostics 2025, 15, 2563. https://doi.org/10.3390/diagnostics15202563

AMA Style

Loutati R, Taha L, Karmi M, Fink N, Sabouret P, A. Mamas M, Naimark A, Tvito A, Wiener-Well Y, Abu-Salman A, et al. Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications. Diagnostics. 2025; 15(20):2563. https://doi.org/10.3390/diagnostics15202563

Chicago/Turabian Style

Loutati, Ranel, Louay Taha, Mohammad Karmi, Noam Fink, Pierre Sabouret, Mamas A. Mamas, Ari Naimark, Ariella Tvito, Yonit Wiener-Well, Amjad Abu-Salman, and et al. 2025. "Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications" Diagnostics 15, no. 20: 2563. https://doi.org/10.3390/diagnostics15202563

APA Style

Loutati, R., Taha, L., Karmi, M., Fink, N., Sabouret, P., A. Mamas, M., Naimark, A., Tvito, A., Wiener-Well, Y., Abu-Salman, A., Shuvy, M., Merin, O., Glikson, M., & Asher, E. (2025). Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications. Diagnostics, 15(20), 2563. https://doi.org/10.3390/diagnostics15202563

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Shifting Trends in Intensive Cardiovascular Care Unit Admission Patterns: Retrospective Insights and Prospective Implications

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