Exploring Chromogranin A (CgA) as a Diagnostic Marker in Hypothermia-Related Deaths: Two Case Studies and a Literature Review
Abstract
1. Introduction
2. Case Presentation
2.1. Case 1
2.1.1. Autopsy
2.1.2. Histopathology
2.2. Case 2
2.2.1. Autopsy
2.2.2. Histopathology
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
CgA | Chromogranin A |
HPA | Hypothalamic–pituitary–adrenal |
IHC | Immunohistochemistry |
WSs | Wischnewsky spots |
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Available Data of the Cases | ||
---|---|---|
Parameter | Case 1 | Case 2 |
Age | 67 years | 49 years |
Location found | Snowy country road | Secluded wooded area |
Ambient temperature (°C) | −1 to 2 °C | 1 to 3 °C |
Time to autopsy | 12 h refrigerated | 18 h refrigerated |
Key autopsy findings | WSs, cerebral/pulmonary edema, petechiae | WSs, cerebral/pulmonary edema, dermal vessel dilation |
CgA adrenal medulla | Strong positivity | Strong positivity |
CgA pancreatic islets | Strong positivity | Strong positivity |
CgA hypothalamus | Not assessed | Not assessed |
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Tomassini, L.; Buratti, E.; Ricchezze, G.; Scendoni, R. Exploring Chromogranin A (CgA) as a Diagnostic Marker in Hypothermia-Related Deaths: Two Case Studies and a Literature Review. Diagnostics 2025, 15, 1673. https://doi.org/10.3390/diagnostics15131673
Tomassini L, Buratti E, Ricchezze G, Scendoni R. Exploring Chromogranin A (CgA) as a Diagnostic Marker in Hypothermia-Related Deaths: Two Case Studies and a Literature Review. Diagnostics. 2025; 15(13):1673. https://doi.org/10.3390/diagnostics15131673
Chicago/Turabian StyleTomassini, Luca, Erika Buratti, Giulia Ricchezze, and Roberto Scendoni. 2025. "Exploring Chromogranin A (CgA) as a Diagnostic Marker in Hypothermia-Related Deaths: Two Case Studies and a Literature Review" Diagnostics 15, no. 13: 1673. https://doi.org/10.3390/diagnostics15131673
APA StyleTomassini, L., Buratti, E., Ricchezze, G., & Scendoni, R. (2025). Exploring Chromogranin A (CgA) as a Diagnostic Marker in Hypothermia-Related Deaths: Two Case Studies and a Literature Review. Diagnostics, 15(13), 1673. https://doi.org/10.3390/diagnostics15131673