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Article

Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia

by
Maria T. Papadopoulou
1,2,*,
Paraskevi Panagopoulou
1,
Efstathia Paramera
3,
Alexandros Pechlivanis
4,5,
Christina Virgiliou
5,6,
Eugenia Papakonstantinou
7,
Maria Palabougiouki
8,
Maria Ioannidou
8,
Eleni Vasileiou
8,
Athanasios Tragiannidis
8,
Evangelos Papakonstantinou
3,
Georgios Theodoridis
4,5,
Emmanuel Hatzipantelis
8 and
Athanasios Evangeliou
1,9
1
4th Pediatric Department, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road, Nea Efkarpia, 56403 Thessaloniki, Greece
2
Woman-Mother-Child Hospital, University Hospitals of Lyon, 69500 Bron, France
3
NEOLAB S.A., Medical Laboratory, 11527 Athens, Greece
4
Department of Chemistry, Aristotle University of Thessaloniki, 54635 Thessaloniki, Greece
5
BIOMIC_Auth, Center for Interdisciplinary Research of the Aristotle University of Thessaloniki (CIRI), Balkan Center, 10th Km Thessaloniki-Thermi Rd, P.O. Box 8318, 57001 Thessaloniki, Greece
6
Analytical Chemistry Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
7
Department of Pediatric Oncology, Ippokratio General Hospital, 54642 Thessaloniki, Greece
8
Pediatric & Adolescents Hematology-Oncology Unit, 2nd Pediatric Department, AHEPA Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
9
St Luke’s Hospital S.A., 55236 Pannorama, Greece
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(7), 682; https://doi.org/10.3390/diagnostics14070682
Submission received: 24 January 2024 / Revised: 11 March 2024 / Accepted: 18 March 2024 / Published: 24 March 2024
(This article belongs to the Special Issue Diagnosis and Management of Pediatric Leukemia)
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Abstract

Introduction: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy. Despite high cure rates, several questions remain regarding predisposition, response to treatment, and prognosis of the disease. The role of intermediary metabolism in the individualized mechanistic pathways of the disease is unclear. We have hypothesized that children with any (sub)type of ALL have a distinct metabolomic fingerprint at diagnosis when compared: (i) to a control group; (ii) to children with a different (sub)type of ALL; (iii) to the end of the induction treatment. Materials and Methods: In this prospective case–control study (NCT03035344), plasma and urinary metabolites were analyzed in 34 children with ALL before the beginning (D0) and at the end of the induction treatment (D33). Their metabolic fingerprint was defined by targeted analysis of 106 metabolites and compared to that of an equal number of matched controls. Multivariate and univariate statistical analyses were performed using SIMCAP and scripts under the R programming language. Results: Metabolomic analysis showed distinct changes in patients with ALL compared to controls on both D0 and D33. The metabolomic fingerprint within the patient group differed significantly between common B-ALL and pre-B ALL and between D0 and D33, reflecting the effect of treatment. We have further identified the major components of this metabolic dysregulation, indicating shifts in fatty acid synthesis, transfer and oxidation, in amino acid and glycerophospholipid metabolism, and in the glutaminolysis/TCA cycle. Conclusions: The disease type and time point-specific metabolic alterations observed in pediatric ALL are of particular interest as they may offer potential for the discovery of new prognostic biomarkers and therapeutic targets.
Keywords: metabolomics; fatty acids; amino acids; organic acids; therapeutic metabolic pathways metabolomics; fatty acids; amino acids; organic acids; therapeutic metabolic pathways

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MDPI and ACS Style

Papadopoulou, M.T.; Panagopoulou, P.; Paramera, E.; Pechlivanis, A.; Virgiliou, C.; Papakonstantinou, E.; Palabougiouki, M.; Ioannidou, M.; Vasileiou, E.; Tragiannidis, A.; et al. Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia. Diagnostics 2024, 14, 682. https://doi.org/10.3390/diagnostics14070682

AMA Style

Papadopoulou MT, Panagopoulou P, Paramera E, Pechlivanis A, Virgiliou C, Papakonstantinou E, Palabougiouki M, Ioannidou M, Vasileiou E, Tragiannidis A, et al. Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia. Diagnostics. 2024; 14(7):682. https://doi.org/10.3390/diagnostics14070682

Chicago/Turabian Style

Papadopoulou, Maria T., Paraskevi Panagopoulou, Efstathia Paramera, Alexandros Pechlivanis, Christina Virgiliou, Eugenia Papakonstantinou, Maria Palabougiouki, Maria Ioannidou, Eleni Vasileiou, Athanasios Tragiannidis, and et al. 2024. "Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia" Diagnostics 14, no. 7: 682. https://doi.org/10.3390/diagnostics14070682

APA Style

Papadopoulou, M. T., Panagopoulou, P., Paramera, E., Pechlivanis, A., Virgiliou, C., Papakonstantinou, E., Palabougiouki, M., Ioannidou, M., Vasileiou, E., Tragiannidis, A., Papakonstantinou, E., Theodoridis, G., Hatzipantelis, E., & Evangeliou, A. (2024). Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia. Diagnostics, 14(7), 682. https://doi.org/10.3390/diagnostics14070682

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