Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Enrollment
2.2. Evaluation of Eosinophilia and CT Scan
2.3. Acquisition and Preprocessing of Temporal Bone Computed Tomography Scan and Lesion Segmentation
2.4. Statistical Analysis
3. Results
3.1. Differential Diagnosis of EOM, GPA, and PCD
3.2. Diagnostic Performance of Blood Eosinophilia for EOM Compared to OME
3.3. Diagnostic Performance of Blood Eosinophilia for EOM Compared to OME
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
Appendix B
EOM | OME | p-Value | |
---|---|---|---|
Protympanum, % | 88.2 | 54.5 | 0.024 * |
Retrotympanum, % | 47.1 | 59.1 | 0.455 |
Protympanum only, % | 41.2 | 4.5 | 0.005 * |
Eustachian tube, % | 58.8 | 45.5 | 0.408 |
Mastoid cavity, % | 35.3 | 68.2 | 0.041 * |
Pneumatization, mean grade (SD) | 3.1 (0.8) | 2.1 (0.8) | 0.001 *,a |
Ears, n | 17 | 22 |
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EOM | GPA | PCD | p-Value | |
---|---|---|---|---|
Age, mean (SD), years | 55.7 (7.7) | 53.9 (17.9) | 27.0 (17.6) | 0.009 *,a |
Male, n (%) | 3 (33.3) | 5 (41.7) | 3 (50.0) | 0.810 |
Bilateral otitis media, n (%) | 8 (88.9) | 4 (33.3) | 5 (100.0) | 0.004 * |
Nasal polyp, n (%) | 8 (88.9) | 2 (16.7) | 5 (83.3) | 0.001 * |
Chronic sinusitis, n (%) | 9 (100.0) | 11 (91.7) | 6 (100.0) | 0.545 |
Patients, n | 9 | 12 | 6 |
EOM | OME | |
---|---|---|
Age, mean (SD), years | 55.7 (7.7) | 55.4 (14.3) |
Male, n (%) | 3 (33.3) | 122 (54.2) |
Mean eosinophil concentration, % (SD) | 12.10 (4.23) | 2.63 (2.70) |
>6, n (%) | 9 (100) | 23 (10.2) |
≤6, n (%) | 0 (0) | 202 (89.8) |
Mean eosinophil count (/μL) | 850 (265.7) | 162.8 (216.1) |
>450, n (%) | 9 (100) | 13 (5.8) |
≤450, n (%) | 0 (0) | 212 (94.2) |
Total, n (%) | 9 (100) | 225 (100) |
Involvement/Pneumatization | EOM | GPA | PCD | p-Value |
---|---|---|---|---|
Protympanum, % | 88.2 | 55.6 | 75.0 | 0.096 |
Retrotympanum, % | 47.1 | 50.0 | 100.0 | 0.029 * |
Protympanum only, % | 41.2 | 5.6 | 0 | 0.008 * |
Eustachian tube, % | 58.8 | 38.9 | 37.5 | 0.424 |
Mastoid cavity, % | 35.3 | 61.1 | 100 | 0.009 * |
Pneumatization, mean grade (SD) | 3.1 (0.8) c | 2.4 (1.2) b | 1.1 (0.4) b,c | <0.001 *,a |
Ears, n | 17 | 18 | 8 |
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Jeong, Y.; Na, G.; Ha, J.-G.; Kim, D.; Kim, J.; Bae, S. Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels. Diagnostics 2023, 13, 3598. https://doi.org/10.3390/diagnostics13233598
Jeong Y, Na G, Ha J-G, Kim D, Kim J, Bae S. Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels. Diagnostics. 2023; 13(23):3598. https://doi.org/10.3390/diagnostics13233598
Chicago/Turabian StyleJeong, Yeonsu, Gina Na, Jong-Gyun Ha, Dachan Kim, Junyup Kim, and Seonghoon Bae. 2023. "Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels" Diagnostics 13, no. 23: 3598. https://doi.org/10.3390/diagnostics13233598
APA StyleJeong, Y., Na, G., Ha, J.-G., Kim, D., Kim, J., & Bae, S. (2023). Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels. Diagnostics, 13(23), 3598. https://doi.org/10.3390/diagnostics13233598