Extracorporeal Membrane Oxygenation (ECMO)-Associated Coagulopathy in Adults

Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsI congratulate the authors to provide a comprehensive view on the topic of coagulopathy on ECMO. The topic is well researched and presented. However, I have few comments:
1. It would be nice if author could provide a diagram showing pathogenesis of caoagulopathy on ECMO as described in the text.
2. Please describe in the table 1 a column of various values of the test.
3. Please provide a table/algorithm for management of the coagulopathy.
4. Please dedicate a heading on diffrerences in coagulopathy in VV vs VA ECMO and more so in Central Vs Peripheral VA ECMO.
5. Please also contribute a section on Paediatric part.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsDear authors,
my compliments on this work.
The issue you are dealing with is very relevant to our current practice, as thrombotic/bleeding issue remain an unsolved problem when using mechanical circulatory support in general, and ECMO in particular, rendering the use of these devices often problematic and sometimes accounts for a limit in their use. The article you wrote presents us is valid in that it presents this issue and analyses our current strategies and tools. i find it a very valuable summary of existing data and a possible starting point for further researxh.
Comments on the Quality of English Language
Very good quality, a few minor adjustments (mainly with use of commas), need to be made.
Author Response
We thank the reviewer for the kind comments. We have made the recommended adjustments
Reviewer 3 Report
Comments and Suggestions for AuthorsFrantzeskaki and collegues provided an excellent overview about EAC.
Author Response
We appreciate the kind comment.
Round 2
Reviewer 1 Report
Comments and Suggestions for AuthorsVery well conceptualised, researched and presented on a relevant topic. Well done.