Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
Abstract
:1. Introduction
2. Methods
2.1. Inclusion Criteria
2.2. Exclusion Criteria
2.3. Baseline Patient Data
2.4. Baseline Control Data
2.5. Data Assessed at Six Months after Renal Biopsy
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | MCD | FSGS | Membranous Nephropathy | Control | p Value |
---|---|---|---|---|---|
(n = 5) | (n = 18) | (n = 14) | (n = 10) | ||
Age (years), mean ± SD | 37.60 ± 15 | 33.67 ± 13.60 | 42.15 ± 19.64 | 33.60 ± 6.63 | 0.63 |
Male sex, n (%) | 1 (20.0) | 10 (55.6) | 6 (42.9) | 3 (30.0) | <0.0001 |
Serum creatinine (mg/dL), median (IQR) | 0.90 (0.76–1.95) | 2 (0.92–2.62) | 0.65 (0.50–1.17) | 1.11 (0.98–1.18) | 0.086 |
Protein-to-creatinine ratio (g/g), median (IQR) | 3.10 (1.04–3.46) | 4.05 (1.87–5.44) | 4.42 (2.38–7.14) | 0.003 (0–0.22) | <0.0001 |
Serum albumin (g/dL), mean ± SD | 2.08 ± 0.99 | 2.06 ± 0.87 | 2.25 ± 0.54 | - | 0.10 |
CD80 (ng/g creatinine), median (IQR) | 104 (19.70–369.60) | 63.15 (30.50–244.60) | 76.80 (31.22–402.20) | 24.70 (15.10–41.40) | 0.048 ‡ |
suPAR (pg/mL), median (IQR) | 3266 (2887–4225) | 3887 (2359–4620) | 3091 (2018–3711) | 1336 (1033–1586) | 0.0001 * |
Characteristic | MCD + FSGS | Membrane Nephropathy | Other Glomerulopathies | Control | p Value |
---|---|---|---|---|---|
(n = 23) | (n = 14) | (n = 33) | (n = 10) | ||
Age (years), mean ± SD | 34.52 ± 13.65 | 42.15 ± 19.64 | 41.04 ± 15.68 | 33.60 ± 6.63 | 0.24 |
Male sex, n (%) | 11 (47.8) | 6 (42.9) | 8 (28.6) | 3 (30.0) | 0.49 |
Serum creatinine (mg/dL), median (IQR) | 1.80 (0.89–2.50) | 0.65 (0.50–1.17) | 1.39 (0.72–2.10) | 1.11 (0.98–1.18) | 0.16 |
Protein-to-creatinine ratio (g/g), median (IQR) | 3.50 (1.50–4.90) | 4.42 (2.38–7.14) | 2.11 (1.01–5.32) | 0.003 (0–0.22) | <0.0001 |
CD80 (ng/g creatinine), median (IQR) | 80 (33–266.6) | 76.80 (31.22–402.20) | 27.15 (14.53–76.55) | 24.70 (15.10–41.40) | 0.005 * |
suPAR (pg/mL), median (IQR) | 3597 (2424–4531) | 3091 (2018–3711) | 3148 (2431–4015) | 1336 (1033–1586) | <0.0001 † |
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Zen, R.d.C.; Dominguez, W.V.; Braga, I.; dos Reis, L.M.; Jorge, L.B.; Yu, L.; Woronik, V.; Dias, C.B. Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil. Diagnostics 2023, 13, 203. https://doi.org/10.3390/diagnostics13020203
Zen RdC, Dominguez WV, Braga I, dos Reis LM, Jorge LB, Yu L, Woronik V, Dias CB. Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil. Diagnostics. 2023; 13(2):203. https://doi.org/10.3390/diagnostics13020203
Chicago/Turabian StyleZen, Renata de Cássia, Wagner Vasques Dominguez, Ivone Braga, Luciene Machado dos Reis, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, and Cristiane Bitencourt Dias. 2023. "Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil" Diagnostics 13, no. 2: 203. https://doi.org/10.3390/diagnostics13020203
APA StyleZen, R. d. C., Dominguez, W. V., Braga, I., dos Reis, L. M., Jorge, L. B., Yu, L., Woronik, V., & Dias, C. B. (2023). Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil. Diagnostics, 13(2), 203. https://doi.org/10.3390/diagnostics13020203