Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Case 1
3.2. Case 2
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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References | Number of Cases | Primitive or Metastatic | Immunohistochemistry | Outcome |
---|---|---|---|---|
Fushimi et al. [5] | 1 | Primitive: presence of intrathymic nevus | S100 and HMB45 positive in melanoma cells; S100 positive and HMB45 negative in nevus cells | Lung metastases after 1 year |
Shimizu et al. [6] | 1 | Primitive | HMB45, S100, NES, and Chromogranin positive | Alive with no evidence of disease (54 months) |
Taniguchi et al. [8] | 1 | Primitive | HMB45 and S100 positive | Multiple bone metastases after 5 months, alive with the disease (14 months) |
Alli et al. [7] | 1 | Primitive | HMB45 and S100 positive; weak positivity for cytokeratin and neuroendocrine markers, and CD34 negative | Lung metastases after 14 months |
Bavi et al. [9] | 1 | Primitive | S100, Vimentin, and HMB45 positive; CD5 and cytokeratin negative | Post-operative death |
Knipe et al. [10] | 1 | Metastatic | Melan A, HMB45, and S100 positive | Not available |
Katsura et al. [11] | 1 | Primitive | HMB45 and S100 positive | Free of disease |
Present case (1) | 1 | Primitive | Melan A, HMB45, SOX10, and S100 positive; BRAF and EWSR wild-type | Free of disease |
Present case (2) | 1 | Metastatic | Melan A, HMB45, SOX10, and S100 positive; BRAF V600E mutation | Free of disease |
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Cannone, G.; Verzeletti, V.; Fortarezza, F.; Pezzuto, F.; Polverosi, R.; Faccioli, E.; Comacchio, G.M.; Dell’Amore, A.; Rea, F.; Schiavon, M.; et al. Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature. Diagnostics 2023, 13, 2017. https://doi.org/10.3390/diagnostics13122017
Cannone G, Verzeletti V, Fortarezza F, Pezzuto F, Polverosi R, Faccioli E, Comacchio GM, Dell’Amore A, Rea F, Schiavon M, et al. Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature. Diagnostics. 2023; 13(12):2017. https://doi.org/10.3390/diagnostics13122017
Chicago/Turabian StyleCannone, Giorgio, Vincenzo Verzeletti, Francesco Fortarezza, Federica Pezzuto, Roberta Polverosi, Eleonora Faccioli, Giovanni Maria Comacchio, Andrea Dell’Amore, Federico Rea, Marco Schiavon, and et al. 2023. "Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature" Diagnostics 13, no. 12: 2017. https://doi.org/10.3390/diagnostics13122017
APA StyleCannone, G., Verzeletti, V., Fortarezza, F., Pezzuto, F., Polverosi, R., Faccioli, E., Comacchio, G. M., Dell’Amore, A., Rea, F., Schiavon, M., & Calabrese, F. (2023). Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature. Diagnostics, 13(12), 2017. https://doi.org/10.3390/diagnostics13122017