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Review
Peer-Review Record

Haemostasis and Inflammatory Parameters as Potential Diagnostic Biomarkers for VTE in Trauma-Immobilized Patients

Diagnostics 2023, 13(1), 150; https://doi.org/10.3390/diagnostics13010150
by Noor Nabila Ramli 1,2, Salfarina Iberahim 1,2,*, Noor Haslina Mohd Noor 1,2, Zefarina Zulkafli 1,2, Tengku Muzaffar Tengku Md Shihabuddin 1,3, Mohd Hadizie Din 1,3, Muhamad Aizat Mohamed Saat 1,3 and Ahmad Hadif Zaidin Samsudin 1,4
Reviewer 1: Anonymous
Reviewer 2:
Diagnostics 2023, 13(1), 150; https://doi.org/10.3390/diagnostics13010150
Submission received: 16 November 2022 / Revised: 10 December 2022 / Accepted: 12 December 2022 / Published: 2 January 2023
(This article belongs to the Special Issue Haematology: Diagnosis and Management)

Round 1

Reviewer 1 Report

This is a very interesting and comprehensive narrative review that discusses possible biomarkers that can be used for predicting of VTE development in trauma patients. The review is well written and provides a lot of useful information on what is currently known about the subject.

My only suggestion is to add a section about imaging biomarkers. Duplex ultrasound is used as a screening test in trauma patients. While performing duplex ultrasound some markers can be registered such as flow velocity, spontaneous hyperechogenesity, etc. It would make a review more interesting if the information on the imaging biomarkers would be included.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The authors analyzed in this review several biomarkers associated to the risk of developing DVT in patients with trauma. The paper is well written and exhaustive. Only few suggestions for the authors:

-          A table summarizing main data of each biomarkers can be added making readers more confident with these data.

-          Since most cited biomarkers are not currently evaluated in clinic management of patients with trauma, which one do the authors consider most promising to assess the risk of DVT and how would they modify antithrombotic prophylaxis according to them?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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