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Article

Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation

1
Department of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, Germany
2
Department of General Internal Medicine, Nephrology and Rheumatology, University Hospital Münster, 48149 Münster, Germany
3
Diaspective Vision GmbH, 18233 Am Salzhaff, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Antonio Basile and Antonio Granata
Diagnostics 2022, 12(5), 1194; https://doi.org/10.3390/diagnostics12051194
Received: 30 April 2022 / Revised: 8 May 2022 / Accepted: 9 May 2022 / Published: 10 May 2022
(This article belongs to the Special Issue Imaging in Kidney Disease 2.0)
The aim of our study was to evaluate hyperspectral imaging (HSI) as a rapid, non-ionizing technique for the assessment of organ quality and the prediction of delayed graft function (DGF) in kidney transplantation after static cold storage (SCS, n = 20), as well as hypothermic machine perfusion (HMP, n = 18). HSI assessment of the kidney parenchyma was performed during organ preservation and at 10 and 30 min after reperfusion using the TIVITA® Tissue System (Diaspective Vision GmbH, Am Salzhaff, Germany), calculating oxygen saturation (StO2), near-infrared perfusion index (NIR), tissue haemoglobin index (THI), and tissue water index (TWI). Recipient and donor characteristics were comparable between organ preservation groups. Cold ischemic time was significantly longer in the HMP group (14.1 h [3.6–23.1] vs. 8.7h [2.2–17.0], p = 0.002). The overall presence of DGF was comparable between groups (HMP group n = 10 (55.6%), SCS group n = 10 (50.0%)). Prediction of DGF was possible in SCS and HMP kidneys; StO2 at 10 (50.00 [17.75–76.25] vs. 63.17 [27.00–77.75]%, p = 0.0467) and 30 min (57.63 [18.25–78.25] vs. 65.38 [21.25–83.33]%, p = 0.0323) after reperfusion, as well as NIR at 10 (41.75 [1.0–58.00] vs. 48.63 [12.25–69.50], p = 0.0137) and 30 min (49.63 [8.50–66.75] vs. 55.80 [14.75–73.25], p = 0.0261) after reperfusion were significantly lower in DGF kidneys, independent of the organ preservation method. In conclusion, HSI is a reliable method for intraoperative assessment of renal microperfusion, applicable after organ preservation through SCS and HMP, and predicts the development of DGF. View Full-Text
Keywords: hyperspectral imaging; delayed graft function; hypothermic machine perfusion; kidney transplantation; organ preservation hyperspectral imaging; delayed graft function; hypothermic machine perfusion; kidney transplantation; organ preservation
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MDPI and ACS Style

Romann, S.; Wagner, T.; Katou, S.; Reuter, S.; Vogel, T.; Becker, F.; Morgul, H.; Houben, P.; Wahl, P.; Pascher, A.; Radunz, S. Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation. Diagnostics 2022, 12, 1194. https://doi.org/10.3390/diagnostics12051194

AMA Style

Romann S, Wagner T, Katou S, Reuter S, Vogel T, Becker F, Morgul H, Houben P, Wahl P, Pascher A, Radunz S. Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation. Diagnostics. 2022; 12(5):1194. https://doi.org/10.3390/diagnostics12051194

Chicago/Turabian Style

Romann, Sophie, Tristan Wagner, Shadi Katou, Stefan Reuter, Thomas Vogel, Felix Becker, Haluk Morgul, Philipp Houben, Philip Wahl, Andreas Pascher, and Sonia Radunz. 2022. "Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation" Diagnostics 12, no. 5: 1194. https://doi.org/10.3390/diagnostics12051194

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