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Article

Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

by
Claudia Monica Danilescu
1,†,
Mihaela Ionescu
2,†,
Daniela Larisa Sandulescu
3,*,
Mihail Cristian Pirlog
4,*,
Costin Teodor Streba
5 and
Ion Rogoveanu
3
1
Doctoral School, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
2
Department of Medical Informatics and Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Department of Medical Sociology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
5
Department of Scientific Research Methodology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2022, 12(5), 1177; https://doi.org/10.3390/diagnostics12051177
Submission received: 25 March 2022 / Revised: 29 April 2022 / Accepted: 6 May 2022 / Published: 9 May 2022
(This article belongs to the Special Issue Diagnosis and Management of Hepatitis C)
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Abstract

The Hepatitis C Virus (HCV) infection often associates medical and mental health conditions which lead to increased levels of distress. Our study aimed at assessing the level of perceived stress on a sample of 90 HCV infected patients treated with Direct-Acting Antiviral (DAA) agents for 12 weeks, and its possible correlations with clinical and evolutionary elements. The evaluation was conducted in three phases: before administration of the DAAs (BSL), at the End of the Treatment (EOT), and 24 weeks after the BSL (Sustained Viral Response—SVR). The perceived stress was measured using the Perceived Stress Scale (PSS). The efficiency of the DAA treatment reduced the levels of stress (98.99% moderate and high stress at BSL to 70.00% at SVR). It was observed, for the entire study period (BSL to SVR), that the decrease in the perceived stress severity was significantly associated with demographic items such as gender (p < 0.01), urban environment (p < 0.001), the age of the subjects (p < 0.05), and clinical data such as F4 degree of fibrosis (p = 0.001) and overweight or obesity class II (p < 0.01). The perceived stress is directly associated with the severity of the HCV infection, and it could be significantly lowered by an efficient therapeutic approach, as DAAs are nowadays.
Keywords: hepatitis C virus; direct acting antivirals; perceived stress; fibrosis; sustained virological response hepatitis C virus; direct acting antivirals; perceived stress; fibrosis; sustained virological response

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MDPI and ACS Style

Danilescu, C.M.; Ionescu, M.; Sandulescu, D.L.; Pirlog, M.C.; Streba, C.T.; Rogoveanu, I. Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy. Diagnostics 2022, 12, 1177. https://doi.org/10.3390/diagnostics12051177

AMA Style

Danilescu CM, Ionescu M, Sandulescu DL, Pirlog MC, Streba CT, Rogoveanu I. Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy. Diagnostics. 2022; 12(5):1177. https://doi.org/10.3390/diagnostics12051177

Chicago/Turabian Style

Danilescu, Claudia Monica, Mihaela Ionescu, Daniela Larisa Sandulescu, Mihail Cristian Pirlog, Costin Teodor Streba, and Ion Rogoveanu. 2022. "Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy" Diagnostics 12, no. 5: 1177. https://doi.org/10.3390/diagnostics12051177

APA Style

Danilescu, C. M., Ionescu, M., Sandulescu, D. L., Pirlog, M. C., Streba, C. T., & Rogoveanu, I. (2022). Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy. Diagnostics, 12(5), 1177. https://doi.org/10.3390/diagnostics12051177

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