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Volume 12
Issue 3
10.3390/diagnostics12030660
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Dissecting Gonadoblastoma of the Ovary Coexistent with an Atypical Endometriotic Cyst: Incidental Detection in Cystectomy Specimen of a Woman with 46,XX Karyotype

by
Hera Jung
1,
Bo Seong Yun
2,
Yoon Yang Jung
3,* and
Hyun-Soo Kim
4,*
1
Department of Pathology, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang 10414, Korea
2
Department of Obstetrics and Gynecology, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang 10414, Korea
3
Department of Pathology, Myongji Hospital, Hanyang University College of Medicine, Goyang 10475, Korea
4
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
*
Authors to whom correspondence should be addressed.
Diagnostics 2022, 12(3), 660; https://doi.org/10.3390/diagnostics12030660
Submission received: 26 January 2022 / Revised: 25 February 2022 / Accepted: 7 March 2022 / Published: 9 March 2022
(This article belongs to the Special Issue Diagnosis and Management of Gynecological Cancers)
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Abstract

Dissecting gonadoblastoma (DGB) of the ovary, a recently described terminology, defines a unique distribution of neoplastic germ cells. Here, we report a case of incidental DGB coexistent with an atypical endometriotic cyst occurring in a 23-year-old woman. The ovarian cyst was lined by endometrial-like glands and stroma. Some glands displayed nuclear enlargement and hyperchromasia, and abundant eosinophilic cytoplasm with occasional intracytoplasmic hemosiderin and mucin vacuoles. The neoplastic germ cells resembled those of ovarian dysgerminoma and were diffusely distributed within the ovarian stroma, which was stretched around the wall of the endometriotic cyst. These cells were arranged in nests and cords, possessing clear cytoplasm and centrally located round nuclei with prominent nucleoli and occasional mitoses. Chromosomal analysis revealed a 46,XX karyotype. We describe the clinical, histological, immunophenotypical, and genetic features of ovarian DGB incidentally detected in the ovarian cystectomy specimen of a woman with normal female karyotype.
Keywords: ovary; dissecting gonadoblastoma; atypical endometriotic cyst; normal karyotype ovary; dissecting gonadoblastoma; atypical endometriotic cyst; normal karyotype

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MDPI and ACS Style

Jung, H.; Yun, B.S.; Jung, Y.Y.; Kim, H.-S. Dissecting Gonadoblastoma of the Ovary Coexistent with an Atypical Endometriotic Cyst: Incidental Detection in Cystectomy Specimen of a Woman with 46,XX Karyotype. Diagnostics 2022, 12, 660. https://doi.org/10.3390/diagnostics12030660

AMA Style

Jung H, Yun BS, Jung YY, Kim H-S. Dissecting Gonadoblastoma of the Ovary Coexistent with an Atypical Endometriotic Cyst: Incidental Detection in Cystectomy Specimen of a Woman with 46,XX Karyotype. Diagnostics. 2022; 12(3):660. https://doi.org/10.3390/diagnostics12030660

Chicago/Turabian Style

Jung, Hera, Bo Seong Yun, Yoon Yang Jung, and Hyun-Soo Kim. 2022. "Dissecting Gonadoblastoma of the Ovary Coexistent with an Atypical Endometriotic Cyst: Incidental Detection in Cystectomy Specimen of a Woman with 46,XX Karyotype" Diagnostics 12, no. 3: 660. https://doi.org/10.3390/diagnostics12030660

APA Style

Jung, H., Yun, B. S., Jung, Y. Y., & Kim, H.-S. (2022). Dissecting Gonadoblastoma of the Ovary Coexistent with an Atypical Endometriotic Cyst: Incidental Detection in Cystectomy Specimen of a Woman with 46,XX Karyotype. Diagnostics, 12(3), 660. https://doi.org/10.3390/diagnostics12030660

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