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Article

Intracranial Meningioma in Elderly Patients. Retrospective Multicentric Risk and Surgical Factors Study of Morbidity and Mortality

1
Neurosurgery Division, Human Neurosciences Department, “Sapienza” University, 00185 Rome, Italy
2
Santa Maria Goretti Hospital, 04100 Latina, Italy
3
Neurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10124 Turin, Italy
4
Neurosurgery Department, Fabrizio Spaziani Hospital, 03100 Frosinone, Italy
5
Policlinico Tor Vergata, University Tor Vergata of Rome, 00133 Rome, Italy
6
IRCCS “Neuromed”, 86077 Pozzilli, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Luca Falzone and Massimo Moro
Diagnostics 2022, 12(2), 351; https://doi.org/10.3390/diagnostics12020351
Received: 5 January 2022 / Revised: 20 January 2022 / Accepted: 27 January 2022 / Published: 29 January 2022
(This article belongs to the Topic Cancer Biology and Therapy)
With the increasing life expectancy, a large number of intracranial meningiomas (IM) have been identified in elderly patients. There is no general consensus regarding the management for IMs nor studies regarding the outcome of older patients undergoing meningioma surgery. We aimed to determine whether preoperative variables and postoperative clinical outcomes differ between age groups after meningioma surgery. We analyzed data from all patients who had undergone IM surgery from our departments. The final cohort consisted of 340 patients affected by IM with ASA class I-II: 188 in the young group (<65) and 152 in the elderly. The two subgroups did not present significant differences concerning biological characteristics of tumor, localization, diameters, lesion and edema volumes and surgical radicality. Despite these comparable data, elderly presented with a significantly lower Karnofsky Performance status value on admission and remained consistently lower during the follow-up. We establish instead that there is no intrinsic correlation to the presence of IM and no significant increased risk of complications or recurrence in elderly patients, but rather only an increased risk of reduced performance status with mortality related to the comorbidity of the patient, primarily cardiovascular disease, and an intrinsic frailty of the aged population. View Full-Text
Keywords: meningioma; elderly patient; neurosurgery; brain tumor; risk factors meningioma; elderly patient; neurosurgery; brain tumor; risk factors
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MDPI and ACS Style

Armocida, D.; Arcidiacono, U.A.; Palmieri, M.; Pesce, A.; Cofano, F.; Picotti, V.; Salvati, M.; D’Andrea, G.; Garbossa, D.; Santoro, A.; Frati, A. Intracranial Meningioma in Elderly Patients. Retrospective Multicentric Risk and Surgical Factors Study of Morbidity and Mortality. Diagnostics 2022, 12, 351. https://doi.org/10.3390/diagnostics12020351

AMA Style

Armocida D, Arcidiacono UA, Palmieri M, Pesce A, Cofano F, Picotti V, Salvati M, D’Andrea G, Garbossa D, Santoro A, Frati A. Intracranial Meningioma in Elderly Patients. Retrospective Multicentric Risk and Surgical Factors Study of Morbidity and Mortality. Diagnostics. 2022; 12(2):351. https://doi.org/10.3390/diagnostics12020351

Chicago/Turabian Style

Armocida, Daniele, Umberto A. Arcidiacono, Mauro Palmieri, Alessandro Pesce, Fabio Cofano, Veronica Picotti, Maurizio Salvati, Giancarlo D’Andrea, Diego Garbossa, Antonio Santoro, and Alessandro Frati. 2022. "Intracranial Meningioma in Elderly Patients. Retrospective Multicentric Risk and Surgical Factors Study of Morbidity and Mortality" Diagnostics 12, no. 2: 351. https://doi.org/10.3390/diagnostics12020351

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