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Review

OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives

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Department of Oncology and Neurosurgery, University Clinic, Privolzhsky Research Medical University, 18/1 Verkhnevolzhskaya Naberezhnaja, 603155 Nizhny Novgorod, Russia
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Institute of Biomedical Optics, University of Luebeck, Peter-Monnik-Weg 4, D-23562 Luebeck, Germany
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Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Sq., 603950 Nizhny Novgorod, Russia
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Institute of Applied Physics of the Russian Academy of Sciences, 46 Ulyanova St., 603950 Nizhny Novgorod, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Alessio Imperiale
Diagnostics 2022, 12(2), 335; https://doi.org/10.3390/diagnostics12020335
Received: 22 December 2021 / Revised: 19 January 2022 / Accepted: 26 January 2022 / Published: 28 January 2022
Optical coherence tomography (OCT) has been recently suggested as a promising method to obtain in vivo and real-time high-resolution images of tissue structure in brain tumor surgery. This review focuses on the basics of OCT imaging, types of OCT images and currently suggested OCT scanner devices and the results of their application in neurosurgery. OCT can assist in achieving intraoperative precision identification of tumor infiltration within surrounding brain parenchyma by using qualitative or quantitative OCT image analysis of scanned tissue. OCT is able to identify tumorous tissue and blood vessels detection during stereotactic biopsy procedures. The combination of OCT with traditional imaging such as MRI, ultrasound and 5-ALA fluorescence has the potential to increase the safety and accuracy of the resection. OCT can improve the extent of resection by offering the direct visualization of tumor with cellular resolution when using microscopic OCT contact probes. The theranostic implementation of OCT as a part of intelligent optical diagnosis and automated lesion localization and ablation could achieve high precision, automation and intelligence in brain tumor surgery. We present this review for the increase of knowledge and formation of critical opinion in the field of OCT implementation in brain tumor surgery. View Full-Text
Keywords: optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging
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MDPI and ACS Style

Yashin, K.; Bonsanto, M.M.; Achkasova, K.; Zolotova, A.; Wael, A.-M.; Kiseleva, E.; Moiseev, A.; Medyanik, I.; Kravets, L.; Huber, R.; Brinkmann, R.; Gladkova, N. OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives. Diagnostics 2022, 12, 335. https://doi.org/10.3390/diagnostics12020335

AMA Style

Yashin K, Bonsanto MM, Achkasova K, Zolotova A, Wael A-M, Kiseleva E, Moiseev A, Medyanik I, Kravets L, Huber R, Brinkmann R, Gladkova N. OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives. Diagnostics. 2022; 12(2):335. https://doi.org/10.3390/diagnostics12020335

Chicago/Turabian Style

Yashin, Konstantin, Matteo M. Bonsanto, Ksenia Achkasova, Anna Zolotova, Al-Madhaji Wael, Elena Kiseleva, Alexander Moiseev, Igor Medyanik, Leonid Kravets, Robert Huber, Ralf Brinkmann, and Natalia Gladkova. 2022. "OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives" Diagnostics 12, no. 2: 335. https://doi.org/10.3390/diagnostics12020335

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