Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
Round 1
Reviewer 1 Report
The article describes in great details a very important clinicalproblem regarding the rejection of chronic active (CA) T-13 cell mediated rejection (TCMR) of a kidney. The manuscript was prepared, perferctly.
The aims of the work, the exclusion criteria were presented in details.
The discussion has been prepared very clearly, too.
In addition, the article contains a lot of necessary clinical information
for transplantologists, who work with patients after kidney transplantation.
Finally, the manuscript shows the high scientific level of all authors.
Author Response
Dear Mr./Mrs.,
We sincerely appreciate your review, remarks and time dedicated to our work.
Best regards,
Jakub Mizera
Reviewer 2 Report
Jakub Mizera et al. reviewed the CA TCMR criteria, diagnosis and treatment. Overall, it is a good review.
I have a suggestion, in the molecular diagnosis section, the immune repertoire can be added. Recently, TCR and BCR detection using NGS can provide us the T and B cells clone information. It also give us an immune diversity map. It is very helpful for different kinds of rejection diagnosis.
Author Response
Dear Mr./Mrs.
We sincerely appreciate your review, remarks and time dedicated to our work. We applied your suggestions and included (in the Molecular Diagnostics section) the paragraph regarding NGS role in clinical management and prediction of graft failure in patients after kidney transplantation.
Best regards,
Jakub Mizera