Shear Wave Dispersion Slope Measured with Shear Wave Dispersion Imaging Is Associated with Variceal Hemorrhage in Cirrhotic Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Ultrasound Examination
2.3. Laboratory Test
2.4. Statistical Analysis
3. Results
3.1. Comparisons of Variables According to the Presence of VH
3.2. Factors Associated with VH
3.3. Diagnostic Performance for VH
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Non VH (n = 43) | VH (n = 22) | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|---|---|
t/z/χ² | p Value | OR (95% CI) | p Value | |||
Age (years) | 55.65 ± 11.97 | 58.41 ± 11.73 | −0.885 | 0.380 | — | — |
Sex | 0.210 | 0.647 | — | — | ||
Male | 26 (60.5%) | 12 (54.5%) | ||||
Female | 17 (39.5%) | 10 (45.5%) | ||||
BMI (kg/m2) | 23.69 ± 3.53 | 22.47 ± 2.36 | 1.457 | 0.150 | — | — |
Etiology | 7.434 | 0.055 | — | — | ||
Chronic viral hepatitis | 24 (55.8%) | 6 (27.3%) | ||||
PBC | 11 (25.6%) | 5 (22.7%) | ||||
others | 4 (9.3%) | 5 (22.7%) | ||||
Cryptogenic cirrhosis | 4 (9.3%) | 6 (27.3%) | ||||
PLT (×109/L) | 145.44 ± 59.61 | 92.59 ± 38.11 | 3.755 | <0.001 | — | 0.286 |
ALT (IU/L) | 24.80 (17.00–36.20) | 20.50 (14.75–43.18) | −0.284 | 0.776 | — | — |
AST (IU/L) | 28.00 (22.50–43.00) | 34.00 (24.00–49.28) | −1.096 | 0.273 | — | — |
TBIL (μmol/L) | 17.80 (13.00–27.80) | 23.95 (16.88–44.45) | −1.879 | 0.060 | — | — |
ALB (g/L) | 39.96 ± 6.53 | 36.06 ± 4.90 | 2.463 | 0.017 | — | 0.227 |
Ascites | 9.449 | 0.002 | 6.066 (1.287–28.585) | 0.023 | ||
No | 29 (67.4%) | 6 (27.3%) | ||||
Yes | 14 (32.6%) | 16 (72.7%) | ||||
Portal vein diameter (cm) | 1.10 (1.00-1.30) | 1.30 (1.28-1.40) | −3.578 | <0.001 | — | 0.105 |
Spleen diameter (cm) | 11.48 ± 2.71 | 14.36 ± 2.00 | −4.414 | <0.001 | 1.567 (1.126–2.181) | 0.008 |
LS (kPa) | 9.30 (7.40–11.70) | 10.60 (9.10–12.68) | −1.796 | 0.073 | — | — |
SWDS (m/s/kHz) | 15.17 ± 1.88 | 17.04 ± 1.45 | −4.062 | <0.001 | 2.234 (1.267–3.941) | 0.005 |
Criteria | AUC | p Value | Cutoff Value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
---|---|---|---|---|---|---|---|
LS | 0.637 (0.508–0.753) | 0.062 | 9.5 | 77.3 (54.6–92.2) | 53.5 (37.7–68.8) | 45.9 (36.5–55.7) | 82.1 (67.0–91.3) |
SWDS | 0.768 (0.647–0.864) | <0.001 | 15.2 | 95.5 (77.2–99.9) | 53.5 (37.7–68.8) | 51.2 (42.9–59.4) | 95.8 (76.9–99.4) |
Spleen diameter | 0.798 (0.680–0.887) | <0.001 | 12.6 | 81.8 (59.7–94.8) | 67.4 (51.5–80.9) | 56.2 (44.5–67.4) | 87.9 (74.5–94.7) |
Regression-based model | 0.900 (0.800–0.961) | <0.001 | 0.19 | 100.0 (84.6–100) | 72.1 (56.3–84.7) | 64.7 (53.1–74.8) | 100.0 |
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Sun, X.; Zhang, L.; Jiang, L.; Cui, L.; Li, X. Shear Wave Dispersion Slope Measured with Shear Wave Dispersion Imaging Is Associated with Variceal Hemorrhage in Cirrhotic Patients. Diagnostics 2022, 12, 2909. https://doi.org/10.3390/diagnostics12122909
Sun X, Zhang L, Jiang L, Cui L, Li X. Shear Wave Dispersion Slope Measured with Shear Wave Dispersion Imaging Is Associated with Variceal Hemorrhage in Cirrhotic Patients. Diagnostics. 2022; 12(12):2909. https://doi.org/10.3390/diagnostics12122909
Chicago/Turabian StyleSun, Xiaohui, Li Zhang, Ling Jiang, Ligang Cui, and Xiaoguang Li. 2022. "Shear Wave Dispersion Slope Measured with Shear Wave Dispersion Imaging Is Associated with Variceal Hemorrhage in Cirrhotic Patients" Diagnostics 12, no. 12: 2909. https://doi.org/10.3390/diagnostics12122909