Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Statistical Method
3. Results
PLR and NLR as Diagnostic Test for Chronic Disease: OSA-COPD Overlap, Interstitial Lung Diseases and Bronchiectasis
4. Discussion
- NLR was found to be poor as a diagnostic test when we compared healthy persons with patients with chronic respiratory diseases, but not when we compared the diseases.
- PLR seems to be a more reliable marker in differentiating between the evaluated chronic diseases, but as a diagnostic test, it remains poor.
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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COVID-19 Group (n = 145) | Other Disease Group (n = 219) | Control Group (n = 161) | p | |
---|---|---|---|---|
AGE | 46 (33.5, 57) a,b | 62 (52.5, 68) c | 40 (29, 48) | <0.001 ** |
Males, number (%) | 69 (47.6) a,b | 138 (65.1) c | 33 (20.5) | <0.001 ** |
NLR | 2.56 (1.72, 3.79) b | 2.48 (1.85, 3.49) c | 2.03 (1.59, 2.59) | <0.001 ** |
PLR | 151.85 (112.86, 211.59) a,b | 114.1 (92.31, 150.13) | 125.37 (101.78, 156.71) | <0.001 ** |
White blood cells | 5.95 (4.89, 8.05) a | 7.77 (6.25, 9.45) c | 6.3 (5.54, 7.78) | <0.001 ** |
Lymphocytes (103/μL) | 1.56 (1.2, 2.03) a,b | 1.93 (1.52, 2.35) | 1.96 (1.62, 2.34) | <0.001 * |
Neutrophils (103/μL) | 4.01 (2.94, 5.5) a | 4.94 (3.94, 6.34) c | 3.96 (3.19, 4.94) | <0.001 ** |
Thrombocytes (X103) | 249 (183, 299) | 231 (189, 273.5) c | 247 (222, 279) | 0.016 ** |
CRP | 3.25 (0.99, 18.7) | 4.9 (2.2, 11.8) c | 2.55 (1.5, 4.4) | 0.006 ** |
ESR | 12 (5.5, 30) | 15 (7, 28) c | 11 (6, 15) | 0.003 ** |
Cutoff | Sensitivity | Specificity | ||
---|---|---|---|---|
PLR | COVID-19 group (codified with 1) vs. control—AUC = 0.640, p < 0.001 | 90.78 | 0.90 | 0.16 |
112.52 | 0.75 | 0.35 | ||
182.48 | 0.38 | 0.88 | ||
190.48 | 0.33 | 0.90 | ||
COVID-19 group (codified with 1) vs. chronic respiratory disease group—AUC = 0.677, p < 0.001 | 90.5 | 0.90 | 0.24 | |
112.68 | 0.75 | 0.48 | ||
144.95 | 0.56 | 0.73 | ||
195.84 | 0.30 | 0.90 | ||
COVID-19 group (codified with 1) vs. control and chronic respiratory disease group—AUC = 0.662, p < 0.001 | 90.78 | 0.90 | 0.21 | |
112.68 | 0.75 | 0.43 | ||
157.23 | 0.49 | 0.77 | ||
193.55 | 0.30 | 0.90 | ||
NLR | COVID-19 group (codified with 1) vs. control—AUC = 0.624, p < 0.001 | 1.35 | 0.90 | 0.12 |
1.72 | 0.75 | 0.32 | ||
3.02 | 0.39 | 0.88 | ||
3.15 | 0.36 | 0.90 |
OSA-COPD Overlap (n = 85) | Interstitial Lung Diseases (n = 36) | Bronchiectasis (n = 98) | p | |
---|---|---|---|---|
AGE | 61 (51, 65) | 64 (57, 69.5) | 62 (54, 74) | 0.177 |
Gender, number (%) | 66 (84.6) a,b | 20 (55.6) | 52 (53.1) | <0.001 |
NLR | 2.5 (1.87, 3.33) | 2.54 (1.82, 3.76) | 2.38 (1.81, 3.46) | 0.808 |
PLR | 103.93 (84.85, 129.14) a,b | 129.8 (109.62, 165.94) | 129.18 (95.18, 162.43) | 0.001 |
Lymphocytes (103/μL) | 2.04 (1.68, 2.38) a | 1.71 (1.31, 2.06) | 1.95 (1.47, 2.38) | 0.012 |
Neutrophils (103/μL) | 5.41 ± 1.77 a | 4.61 ± 1.79 | 5.57 ± 2.82 | 0.037 |
Platelets (X103) | 224 (189, 256) b | 229.5 (175.5, 274) | 241.5 (202, 295) | 0.043 |
ESR | 8 (5, 19) a,b | 18.5 (12.5, 31) | 20 (11, 34.5) | <0.001 |
CRP | 4.8 (2.4, 11.7) | 3.45 (1.85, 10.15) | 6.05 (1.95, 16.65) | 0.379 |
Cutoff | Sensitivity | Specificity | ||
---|---|---|---|---|
PLR | OSA-COPD group (codified as 0) vs. control—AUC = 0.656, p < 0.001 | 84.41 | 0.90 | 0.17 |
101.82 | 0.75 | 0.48 | ||
114.9 | 0.63 | 0.68 | ||
172.98 | 0.17 | 0.90 | ||
OSA-COPD group (coded with 0) versus interstitial lung disease and bronchiectasis groups—AUC = 0.645, p < 0.001 | 75.14 | 0.90 | 0.24 | |
102.71 | 0.75 | 0.48 | ||
118.38 | 0.58 | 0.71 | ||
173.78 | 0.19 | 0.90 | ||
Interstitial lung disease group (coded with 1) versus OSA-COPD and bronchiectasis groups—AUC = 0.636, p = 0.010 | 101.74 | 0.92 | 0.39 | |
109.62 | 0.75 | 0.47 | ||
148.90 | 0.36 | 0.75 | ||
189.88 | 0.19 | 0.90 | ||
NLR | OSA-COPD group (codified with 1) vs. control—AUC = 0.652, p < 0.001 | 1.56 | 0.90 | 0.22 |
2.19 | 0.69 | 0.57 | ||
2.59 | 0.47 | 0.75 | ||
3.15 | 0.31 | 0.90 | ||
Interstitial lung disease group (codified with 1) vs. control—AUC = 0.672, p = 0.001 | 1.60 | 0.90 | 0.25 | |
1.84 | 0.75 | 0.37 | ||
2.63 | 0.47 | 0.75 | ||
3.31 | 0.39 | 0.92 | ||
Bronchiectasis disease group (codified with 1) vs. control—AUC = 0.672, p = 0.001 | 1.49 | 0.90 | 0.20 | |
1.80 | 0.75 | 0.36 | ||
2.31 | 0.56 | 0.64 | ||
3.15 | 0.29 | 0.90 |
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Man, M.-A.; Davidescu, L.; Motoc, N.-S.; Rajnoveanu, R.-M.; Bondor, C.-I.; Pop, C.-M.; Toma, C. Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis. Diagnostics 2022, 12, 81. https://doi.org/10.3390/diagnostics12010081
Man M-A, Davidescu L, Motoc N-S, Rajnoveanu R-M, Bondor C-I, Pop C-M, Toma C. Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis. Diagnostics. 2022; 12(1):81. https://doi.org/10.3390/diagnostics12010081
Chicago/Turabian StyleMan, Milena-Adina, Lavinia Davidescu, Nicoleta-Stefania Motoc, Ruxandra-Mioara Rajnoveanu, Cosmina-Ioana Bondor, Carmen-Monica Pop, and Claudia Toma. 2022. "Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis" Diagnostics 12, no. 1: 81. https://doi.org/10.3390/diagnostics12010081
APA StyleMan, M.-A., Davidescu, L., Motoc, N.-S., Rajnoveanu, R.-M., Bondor, C.-I., Pop, C.-M., & Toma, C. (2022). Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis. Diagnostics, 12(1), 81. https://doi.org/10.3390/diagnostics12010081