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Article

Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population

1
Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar 751019, India
2
Molecular Biology Laboratory, Department of Microbiology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar 751024, India
3
Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar 751019, India
4
Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, Bhubaneswar 751019, India
*
Author to whom correspondence should be addressed.
Academic Editors: Frediano Inzani and Antonio Maccio
Diagnostics 2022, 12(1), 53; https://doi.org/10.3390/diagnostics12010053
Received: 18 October 2021 / Revised: 18 November 2021 / Accepted: 6 December 2021 / Published: 28 December 2021
(This article belongs to the Special Issue Advance in the Diagnostics of Ovarian Neoplasms)
(1) Background: Lysyl oxidase (LOX) plays a dual role in carcinogenesis and studies show a higher risk of cancer in LOX G473A variants. The present study evaluated the pattern of LOX G473A polymorphism (rs1800449) and serum LOX levels in ovarian cancer patients. (2) Methods: Serum LOX levels were estimated by enzyme linked immunosorbent assay (ELISA). A polymorphism of rs1800449 of LOX gene was detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Selected samples were sequenced for external validation. (3) Results: A majority of study participants were from low socio-economic status. Serum LOX level was significantly higher in ovarian cancer patients as compared to control. Serum LOX level in early-stage ovarian cancer was significantly lower as compared to advanced stage (FIGO stage III & IV). Wild type GG genotype was used as reference. Genotypes AA were associated with a significant risk of epithelial ovarian cancer (OR 3.208; p value- 0.033). A allele of rs1800449 polymorphism of LOX gene, the odds ratio was 1.866 (95% Confidence Interval 1.112–3.16) p value = 0.017 (4) Conclusions: A allele of rs1800449 polymorphism of LOX gene presents an increased risk of ovarian cancer in East Indian population. Serum LOX levels could be a potential biomarker for the diagnosis and prognosis of ovarian cancer. View Full-Text
Keywords: lysyl oxidase; single nucleotide polymorphism; restriction fragment length polymorphism; ovarian cancer lysyl oxidase; single nucleotide polymorphism; restriction fragment length polymorphism; ovarian cancer
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MDPI and ACS Style

Kumari, S.; Patro, A.R.K.; Mishra, B.; Jena, S.K.; Singh, S. Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population. Diagnostics 2022, 12, 53. https://doi.org/10.3390/diagnostics12010053

AMA Style

Kumari S, Patro ARK, Mishra B, Jena SK, Singh S. Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population. Diagnostics. 2022; 12(1):53. https://doi.org/10.3390/diagnostics12010053

Chicago/Turabian Style

Kumari, Suchitra, A. R.K. Patro, Baijayantimala Mishra, Saubhagya K. Jena, and Sweta Singh. 2022. "Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population" Diagnostics 12, no. 1: 53. https://doi.org/10.3390/diagnostics12010053

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