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Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

1
Department of Mathematics and Physics, University of Salento, Monteroni Street, 73100 Lecce, Italy
2
Nanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, Italy
3
Neuro-Oncology Unit, Department of Onco-Haematology, Cell Therapy, Gene Therapy and Haemopoietic Transplant, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
4
Neurosurgery Unit, Department of Neurosciences, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
5
Department Onco-Haematology, and Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
6
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy
7
Nanotechnology Institute, CNR-NANOTEC, c/o La Sapienza University, Piazzale A. Moro, 00165 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editor: Panagiotis Papanagiotou
Diagnostics 2022, 12(1), 173; https://doi.org/10.3390/diagnostics12010173
Received: 23 November 2021 / Revised: 4 January 2022 / Accepted: 7 January 2022 / Published: 12 January 2022
(This article belongs to the Special Issue Advances in Pediatric Neuro-Oncology 2.0)
Pediatric brain tumors represent the most common types of childhood cancer and novel diagnostic and therapeutic solutions are urgently needed. The gold standard treatment option for brain cancers in children, as in adults, is tumor resection followed by radio- and chemotherapy, but with discouraging therapeutic results. In particular, the last two treatments are often associated to significant neurotoxicity in the developing brain of a child, with resulting disabilities such as cognitive problems, neuroendocrine, and neurosensory dysfunctions/deficits. Nanoparticles have been increasingly and thoroughly investigated as they show great promises as diagnostic tools and vectors for gene/drug therapy for pediatric brain cancer due to their ability to cross the blood–brain barrier. In this review we will discuss the developments of nanoparticle-based strategies as novel precision nanomedicine tools for diagnosis and therapy in pediatric brain cancers, with a particular focus on targeting strategies to overcome the main physiological obstacles that are represented by blood–brain barrier. View Full-Text
Keywords: pediatric brain cancers; blood–brain barrier; nanocarriers pediatric brain cancers; blood–brain barrier; nanocarriers
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MDPI and ACS Style

Guido, C.; Baldari, C.; Maiorano, G.; Mastronuzzi, A.; Carai, A.; Quintarelli, C.; De Angelis, B.; Cortese, B.; Gigli, G.; Palamà, I.E. Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers. Diagnostics 2022, 12, 173. https://doi.org/10.3390/diagnostics12010173

AMA Style

Guido C, Baldari C, Maiorano G, Mastronuzzi A, Carai A, Quintarelli C, De Angelis B, Cortese B, Gigli G, Palamà IE. Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers. Diagnostics. 2022; 12(1):173. https://doi.org/10.3390/diagnostics12010173

Chicago/Turabian Style

Guido, Clara, Clara Baldari, Gabriele Maiorano, Angela Mastronuzzi, Andrea Carai, Concetta Quintarelli, Biagio De Angelis, Barbara Cortese, Giuseppe Gigli, and Ilaria E. Palamà. 2022. "Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers" Diagnostics 12, no. 1: 173. https://doi.org/10.3390/diagnostics12010173

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