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Article

Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans

1
Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
2
Siemens Healthineers, 91301 Forchheim, Germany
3
Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Henein
Diagnostics 2021, 11(9), 1708; https://doi.org/10.3390/diagnostics11091708
Received: 10 August 2021 / Revised: 8 September 2021 / Accepted: 13 September 2021 / Published: 18 September 2021
(This article belongs to the Special Issue Advances in Photon Counting Detector Imaging)
We evaluated the accuracy of coronary artery calcium (CAC) scoring on a dual-source photon-counting detector CT (PCD-CT). An anthropomorphic chest phantom underwent ECG-gated sequential scanning on a PCD-CT at 120 kV with four radiation dose levels (CTDIvol, 2.0–8.6 mGy). Polychromatic images at 120 kV (T3D) and virtual monoenergetic images (VMI), from 60 to 75 keV without quantum iterative reconstruction (no QIR) and QIR strength levels 1–4, were reconstructed. For reference, the same phantom was scanned on a conventional energy-integrating detector CT (120 kV; filtered back projection) at identical radiation doses. CAC scoring in 20 patients with PCD-CT (120 kV; no QIR and QIR 1–4) were included. In the phantom, there were no differences between CAC scores of different radiation doses (all, p > 0.05). Images with 70 keV, no QIR (CAC score, 649); 65 keV, QIR 3 (656); 65 keV; QIR4 (648) and T3D, QIR4 (656) showed a <1% deviation to the reference (653). CAC scores significantly decreased at increasing QIR levels (all, p < 0.001) and for each 5 keV-increase (all, p < 0.001). Patient data (median CAC score: 86 [inter-quartile range: 38–978] at 70 keV) confirmed relationships and differences between reconstructions from the phantom. First phantom and in-vivo experience with a clinical dual-source PCD-CT system shows accurate CAC scoring with VMI reconstructions at different radiation dose levels. View Full-Text
Keywords: agatston score; computed tomography; coronary CT angiography; coronary calcium scoring; photon counting computed tomography; virtual monoenergetic imaging agatston score; computed tomography; coronary CT angiography; coronary calcium scoring; photon counting computed tomography; virtual monoenergetic imaging
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MDPI and ACS Style

Eberhard, M.; Mergen, V.; Higashigaito, K.; Allmendinger, T.; Manka, R.; Flohr, T.; Schmidt, B.; Euler, A.; Alkadhi, H. Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans. Diagnostics 2021, 11, 1708. https://doi.org/10.3390/diagnostics11091708

AMA Style

Eberhard M, Mergen V, Higashigaito K, Allmendinger T, Manka R, Flohr T, Schmidt B, Euler A, Alkadhi H. Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans. Diagnostics. 2021; 11(9):1708. https://doi.org/10.3390/diagnostics11091708

Chicago/Turabian Style

Eberhard, Matthias, Victor Mergen, Kai Higashigaito, Thomas Allmendinger, Robert Manka, Thomas Flohr, Bernhard Schmidt, Andre Euler, and Hatem Alkadhi. 2021. "Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans" Diagnostics 11, no. 9: 1708. https://doi.org/10.3390/diagnostics11091708

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