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Article

A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure

1
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital de Valme, 41014 Sevilla, Spain
2
Departamento de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain
3
Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, 14004 Córdoba, Spain
4
Unidad de Medicina Interna y Enfermedades Infecciosas, Hospital de La Princesa, 28006 Madrid, Spain
5
Unidad de Enfermedades Infecciosas, Hospital General Universitario de Alicante, 03010 Alicante, Spain
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Unidad de Patología Infecciosa, Hospital Universitario Alvaro Cunqueiro, Instituto de Investigación Sanitaria Galicia Sur (IISGS), 36312 Vigo, Spain
7
Unidad de Enfermedades Infecciosas, Hospital Universitario Juan Ramón Jiménez, 21005 Huelva, Spain
8
Unidad de Enfermedades Infecciosas y Microbiología, Hospital Virgen de la Victoria, 29010 Málaga, Spain
9
Unidad de Medicina Interna, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain
10
Fundació ACE—Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya (UIC), 08028 Barcelona, Spain
11
CIBERNED Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, 28029 Madrid, Spain
12
Centro Andaluz de Estudios Bioinformáticos (CAEBI, SL), 41013 Sevilla, Spain
13
Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Universidad de Málaga, 29010 Málaga, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Jean-Francois H. Geschwind
Diagnostics 2021, 11(8), 1501; https://doi.org/10.3390/diagnostics11081501
Received: 14 July 2021 / Revised: 11 August 2021 / Accepted: 16 August 2021 / Published: 20 August 2021
(This article belongs to the Special Issue Novel Omic Markers for Diseases Diagnosis)
Liver stiffness (LS) at sustained virological response (SVR) after direct-acting antivirals (DAA)-based therapy is a predictor of liver events in hepatitis C virus (HCV)-infected patients. The study aim was to identify genetic factors associated with LS changes from the moment of starting anti-HCV therapy to SVR. This prospective study included HCV-infected patients from the GEHEP-011 cohort who achieved SVR with DAA-based therapy, with LS pre-treatment ≥ 9.5 kPa and LS measurement available at SVR. Plink and Magma software were used to carry out genome-wide single-nucleotide polymorphism (SNP)-based and gene-based association analyses, respectively. The ShinyGO application was used for exploring enrichment in Gene Ontology (GO) categories for biological processes. Overall, 242 patients were included. Median (quartile 1, quartile 3) LS values at pre-treatment and at SVR were 16.8 (12, 28) kPa and 12.0 (8.5, 19.3) kPa, respectively. Thirty-five SNPs and three genes reached suggestive association with LS changes from the moment of starting anti-HCV therapy to SVR. GO categories related to DNA packaging complex, DNA conformation change, chromosome organization and chromatin organization were significantly enriched. Our study reports possible genetic factors associated with LS changes during HCV-infection cure. In addition, our results suggest that processes related to DNA conformation are also involved in these changes. View Full-Text
Keywords: GWAS; hepatitis C virus infection; polymorphisms; sustained virological response; direct-acting antivirals; liver stiffness GWAS; hepatitis C virus infection; polymorphisms; sustained virological response; direct-acting antivirals; liver stiffness
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MDPI and ACS Style

Corma-Gómez, A.; Macías, J.; Rivero, A.; Rivero-Juarez, A.; de los Santos, I.; Reus-Bañuls, S.; Morano, L.; Merino, D.; Palacios, R.; Galera, C.; Fernández-Fuertes, M.; González-Serna, A.; de Rojas, I.; Ruiz, A.; Sáez, M.E.; Real, L.M.; Pineda, J.A. A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure. Diagnostics 2021, 11, 1501. https://doi.org/10.3390/diagnostics11081501

AMA Style

Corma-Gómez A, Macías J, Rivero A, Rivero-Juarez A, de los Santos I, Reus-Bañuls S, Morano L, Merino D, Palacios R, Galera C, Fernández-Fuertes M, González-Serna A, de Rojas I, Ruiz A, Sáez ME, Real LM, Pineda JA. A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure. Diagnostics. 2021; 11(8):1501. https://doi.org/10.3390/diagnostics11081501

Chicago/Turabian Style

Corma-Gómez, Anaïs, Juan Macías, Antonio Rivero, Antonio Rivero-Juarez, Ignacio de los Santos, Sergio Reus-Bañuls, Luis Morano, Dolores Merino, Rosario Palacios, Carlos Galera, Marta Fernández-Fuertes, Alejandro González-Serna, Itziar de Rojas, Agustín Ruiz, María E. Sáez, Luis M. Real, and Juan A. Pineda. 2021. "A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure" Diagnostics 11, no. 8: 1501. https://doi.org/10.3390/diagnostics11081501

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