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Volume 11
Issue 8
10.3390/diagnostics11081443
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Article

Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index

by
Stephen I. Johnson
1,*,
Daniel Fort
2,
Kenneth J. Shortt
3,
George Therapondos
4,
Gretchen E. Galliano
5,
Theresa Nguyen
1 and
Edward I. Bluth
1,6
1
Department of Radiology, Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121, USA
2
Center for Outcomes Research, Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121, USA
3
Department of Internal Medicine, Northside Hospital Gwinnett, Lawrenceville, GA 30046, USA
4
Multi-Organ Transplant Institute, Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121, USA
5
Department of Pathology, Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121, USA
6
Ochsner Clinical School, The University of Queensland Faculty of Medicine, 1514 Jefferson Hwy., New Orleans, LA 70121, USA
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(8), 1443; https://doi.org/10.3390/diagnostics11081443
Submission received: 9 July 2021 / Revised: 26 July 2021 / Accepted: 29 July 2021 / Published: 10 August 2021
(This article belongs to the Section Medical Imaging and Theranostics)
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Abstract

Hepatorenal index (HRI) has been shown to be an effective, noninvasive ultrasound tool to screen patients for those with or without >5% hepatic steatosis. Objective: The aim of this study was to further refine this HRI tool in order to stratify patients according to their degree of liver steatosis and give direction as to which patients should undergo random liver biopsy. Methods: We conducted a retrospective review of 267 consecutive patients from 2015 to 2017 who had abdominal ultrasounds and a subsequent random liver biopsy within one month. The HRI was calculated and compared with the percent steatosis as assessed by histology. Results: An HRI of ≤1.17 corresponds with >95% positive predictive value of ≤5% steatosis. Between HRI values 1.18 and 1.39, performance of steatosis prediction is mixed. However, for values <1.37 there is an increased likelihood of steatosis ≤5% and likewise the opposite for values >1.37. An HRI of ≥1.4 corresponds with >95% positive predictive value of ≥10% steatosis. Conclusion: HRI is an accurate noninvasive tool to quantify degree of steatosis and guide who should undergo random liver biopsy, potentially significantly reducing the total number of necessary liver biopsies.
Keywords: hepatorenal index; nonalcoholic fatty liver disease; steatosis; ultrasound; liver fat quantification; hepatology; HRI hepatorenal index; nonalcoholic fatty liver disease; steatosis; ultrasound; liver fat quantification; hepatology; HRI

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MDPI and ACS Style

Johnson, S.I.; Fort, D.; Shortt, K.J.; Therapondos, G.; Galliano, G.E.; Nguyen, T.; Bluth, E.I. Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index. Diagnostics 2021, 11, 1443. https://doi.org/10.3390/diagnostics11081443

AMA Style

Johnson SI, Fort D, Shortt KJ, Therapondos G, Galliano GE, Nguyen T, Bluth EI. Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index. Diagnostics. 2021; 11(8):1443. https://doi.org/10.3390/diagnostics11081443

Chicago/Turabian Style

Johnson, Stephen I., Daniel Fort, Kenneth J. Shortt, George Therapondos, Gretchen E. Galliano, Theresa Nguyen, and Edward I. Bluth. 2021. "Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index" Diagnostics 11, no. 8: 1443. https://doi.org/10.3390/diagnostics11081443

APA Style

Johnson, S. I., Fort, D., Shortt, K. J., Therapondos, G., Galliano, G. E., Nguyen, T., & Bluth, E. I. (2021). Ultrasound Stratification of Hepatic Steatosis Using Hepatorenal Index. Diagnostics, 11(8), 1443. https://doi.org/10.3390/diagnostics11081443

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