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Article

Liquid-Based Screening Tests Results: HPV, Liquid-Based Cytology, and P16/Ki67 Dual-Staining in Private-Based Opportunistic Cervical Cancer Screening

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Corfamed Woman’s Health Center, Kluczborska 37, 50-322 Wroclaw, Poland
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Division of Pathology and Clinical Cytology, University Hospital in Wroclaw, Borowska 213, 50-556 Wroclaw, Poland
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Division of Gynecologic Endocrinology, Jagiellonian University Medical College, Kopernika 23, 31-501 Krakow, Poland
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Superior Medical Center, Czyzynska 21/50, 31-571 Krakow, Poland
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Department of Obstetrics and Gynecology, District Public Hospital, Juraszow 7-19, 60-479 Poznan, Poland
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Department of Practical Obstetrics, Wroclaw Medical University, Bartla 5, 51-618 Wroclaw, Poland
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Department of Clinical and Experimental Pathology, Division of Clinical Pathology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editor: Ivana Kholová
Diagnostics 2021, 11(8), 1420; https://doi.org/10.3390/diagnostics11081420
Received: 18 July 2021 / Revised: 30 July 2021 / Accepted: 2 August 2021 / Published: 5 August 2021
(This article belongs to the Special Issue Cervical Cancer Screening, Management, and Prevention)
The baseline data from the private-based opportunistic cervical cancer screening with HRHPV14, liquid-based cytology (LBC) and p16/Ki67 testing, and its quality assessment/quality control (QA/QC) tools are lacking. The age-stratified analysis of 30,066 screening tests results in a Polish population, including the investigation of HRHPV14 status, LBC, and p16/Ki67 dual-staining reporting rates, along with immediate histopathologic correlations, was conducted. For cytopathologic QA/QC, the College of American Pathologists (CAP) benchmarks and enhanced safety protocol were used. The NILM/ASC-US/LSIL/ASC-H/HSIL/AGC reporting rates were 93.9/3.4/2.0/0.22/0.24/0.11, respectively, with correlating HRHPV14-positive rates of 8.4/48.9/77.2/84.6/90.7/26.7. The reporting rates for HSIL (CIN2+) in HRHPV-positive women with NILM/ASC-US/LSIL/ASC-H/HSIL/AGC referred for a colposcopy with biopsy were 19.1/25.8/22.5/12.4/19.1/1.1% of the total HSIL (CIN2+). In total, of the 1130 p16/Ki67 tests, 30% were positive. In NILM HRHPV14-positive women with available histology result, HSIL(CIN2+) was detected in 28.3% of cases. In the first such large-scale Polish study presenting HRHPV14, informed LBC and HSIL (CIN2+) results, the reporting rates were highly consistent with data from American and other CAP-certified laboratories, confirming the possibility of using the 2019 ASCCP risk-based guidelines as one of the screening strategies outside of the US, in conditions of proper QA/QC. The private-based screening model can be effective in cervical cancer prevention, particularly in countries with low population coverage of public funds-based systems. View Full-Text
Keywords: cervical cancer screening; high-risk HPV testing; cervical cytology; p16/Ki67 dual-staining; prevention and control cervical cancer screening; high-risk HPV testing; cervical cytology; p16/Ki67 dual-staining; prevention and control
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MDPI and ACS Style

Trzeszcz, M.; Mazurec, M.; Jach, R.; Mazurec, K.; Jach, Z.; Kotkowska-Szeps, I.; Kania, M.; Wantuchowicz, M.; Prokopyk, A.; Barcikowski, P.; Przybylski, M.; Wach, J.; Halon, A. Liquid-Based Screening Tests Results: HPV, Liquid-Based Cytology, and P16/Ki67 Dual-Staining in Private-Based Opportunistic Cervical Cancer Screening. Diagnostics 2021, 11, 1420. https://doi.org/10.3390/diagnostics11081420

AMA Style

Trzeszcz M, Mazurec M, Jach R, Mazurec K, Jach Z, Kotkowska-Szeps I, Kania M, Wantuchowicz M, Prokopyk A, Barcikowski P, Przybylski M, Wach J, Halon A. Liquid-Based Screening Tests Results: HPV, Liquid-Based Cytology, and P16/Ki67 Dual-Staining in Private-Based Opportunistic Cervical Cancer Screening. Diagnostics. 2021; 11(8):1420. https://doi.org/10.3390/diagnostics11081420

Chicago/Turabian Style

Trzeszcz, Martyna, Maciej Mazurec, Robert Jach, Karolina Mazurec, Zofia Jach, Izabela Kotkowska-Szeps, Magdalena Kania, Mariola Wantuchowicz, Anna Prokopyk, Piotr Barcikowski, Marcin Przybylski, Joanna Wach, and Agnieszka Halon. 2021. "Liquid-Based Screening Tests Results: HPV, Liquid-Based Cytology, and P16/Ki67 Dual-Staining in Private-Based Opportunistic Cervical Cancer Screening" Diagnostics 11, no. 8: 1420. https://doi.org/10.3390/diagnostics11081420

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