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Volume 11
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10.3390/diagnostics11040686
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Article

The Prognostic Value of White-Matter Selective Double Inversion Recovery MRI Sequence in Multiple Sclerosis: An Exploratory Study

by
Francesco Crescenzo
1,2,†,
Damiano Marastoni
1,†,
Anna Isabella Pisani
1,‡,
Agnese Tamanti
1,‡,
Caterina Dapor
1,‡,
Annalisa Colombi
1,
Alessandro Brillo
1,
Roberta Magliozzi
1,
Francesca Benedetta Pizzini
3,
Marco Castellaro
1 and
Massimiliano Calabrese
1,*
1
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy
2
Neurology Unit, Mater Salutis Hospital, Legnago, 37045 Verona, Italy
3
Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy
*
Author to whom correspondence should be addressed.
†
These authors shared the first co-authorship.
‡
These authors contributed equally to this paper.
Diagnostics 2021, 11(4), 686; https://doi.org/10.3390/diagnostics11040686
Submission received: 6 March 2021 / Revised: 8 April 2021 / Accepted: 9 April 2021 / Published: 12 April 2021
(This article belongs to the Section Pathology and Molecular Diagnostics)
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Abstract

Using a white-matter selective double inversion recovery sequence (WM-DIR) that suppresses both grey matter (GM) and cerebrospinal fluid (CSF) signals, some white matter (WM) lesions appear surrounded by a dark rim. These dark rim lesions (DRLs) seem to be specific for multiple sclerosis (MS). They could be of great usefulness in clinical practice, proving to increase the MRI diagnostic criteria specificity. The aims of this study are the identification of DRLs on 1.5 T MRI, the exploration of the relationship between DRLs and disease course, the characterization of DRLs with respect to perilesional normal-appearing WM using magnetization transfer imaging, and the investigation of possible differences in the underlying tissue properties by assessing WM-DIR images obtained at 3.0 T MRI. DRLs are frequent in primary progressive MS (PPMS) patients. Amongst relapsing-remitting MS (RRMS) patients, DRLs are associated with a high risk of the disease worsening and secondary progressive MS (SPMS) conversion after 15 years. The mean magnetization transfer ratio (MTR) of DRLs is significantly different from the lesion without the dark rim, suggesting that DRLs correspond to more destructive lesions.
Keywords: multiple sclerosis; white matter; double inversion recovery; DIR; MRI multiple sclerosis; white matter; double inversion recovery; DIR; MRI

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MDPI and ACS Style

Crescenzo, F.; Marastoni, D.; Pisani, A.I.; Tamanti, A.; Dapor, C.; Colombi, A.; Brillo, A.; Magliozzi, R.; Pizzini, F.B.; Castellaro, M.; et al. The Prognostic Value of White-Matter Selective Double Inversion Recovery MRI Sequence in Multiple Sclerosis: An Exploratory Study. Diagnostics 2021, 11, 686. https://doi.org/10.3390/diagnostics11040686

AMA Style

Crescenzo F, Marastoni D, Pisani AI, Tamanti A, Dapor C, Colombi A, Brillo A, Magliozzi R, Pizzini FB, Castellaro M, et al. The Prognostic Value of White-Matter Selective Double Inversion Recovery MRI Sequence in Multiple Sclerosis: An Exploratory Study. Diagnostics. 2021; 11(4):686. https://doi.org/10.3390/diagnostics11040686

Chicago/Turabian Style

Crescenzo, Francesco, Damiano Marastoni, Anna Isabella Pisani, Agnese Tamanti, Caterina Dapor, Annalisa Colombi, Alessandro Brillo, Roberta Magliozzi, Francesca Benedetta Pizzini, Marco Castellaro, and et al. 2021. "The Prognostic Value of White-Matter Selective Double Inversion Recovery MRI Sequence in Multiple Sclerosis: An Exploratory Study" Diagnostics 11, no. 4: 686. https://doi.org/10.3390/diagnostics11040686

APA Style

Crescenzo, F., Marastoni, D., Pisani, A. I., Tamanti, A., Dapor, C., Colombi, A., Brillo, A., Magliozzi, R., Pizzini, F. B., Castellaro, M., & Calabrese, M. (2021). The Prognostic Value of White-Matter Selective Double Inversion Recovery MRI Sequence in Multiple Sclerosis: An Exploratory Study. Diagnostics, 11(4), 686. https://doi.org/10.3390/diagnostics11040686

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