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Article

Risk Score for Predicting In-Hospital Mortality in COVID-19 (RIM Score)

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Pediatrics Department, HM Hospitales, Fundación de Investigación HM Hospitales, Facultad de Medicina, Universidad CEU San Pablo, 28015 Madrid, Spain
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Fundación de Investigación HM Hospitales, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28015 Madrid, Spain
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Cardiology Department, Hospital Universitario HM Montepríncipe, Grupo HM Hospitales, Fundación de Investigación HM Hospitales, Facultad de Medicina, Universidad CEU San Pablo, Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, 28015 Madrid, Spain
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Anaesthesiology Department, Hospital Universitario HM Sanchinarro, Hospital Universitario Santa Cristina, Fundación de Investigación HM Hospitales, 28015 Madrid, Spain
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Internal Medicine Department, Hospital Universitario HM Sanchinarro, Fundación de Investigación HM Hospitales, 28015 Madrid, Spain
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Emergency Department, Grupo HM Hospitales, Fundación de Investigación HM Hospitales, Facultad de Medicina, Universidad CEU San Pablo, 28015 Madrid, Spain
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Facultad de Medicina, Universidad CEU San Pablo, 28015 Madrid, Spain
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Pediatrics Department, Hospital Universitario HM Puerta del Sur, Móstoles, Fundación de Investigación HM Hospitales, Facultad de Medicina, Universidad CEU San Pablo, 28015 Madrid, Spain
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Pediatrics Department Hospital Universitario HM Nens, Fundación de Investigación HM Hospitales, 08009 Barcelona, Spain
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Medical Management, Hospital Universitario HM Puerta del Sur, Móstoles, Fundación de Investigación HM Hospitales, 28015 Madrid, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Nuno Taveira
Diagnostics 2021, 11(4), 596; https://doi.org/10.3390/diagnostics11040596
Received: 23 February 2021 / Revised: 19 March 2021 / Accepted: 23 March 2021 / Published: 26 March 2021
(This article belongs to the Collection Diagnostic Virology)
Infection by SARS-CoV2 has devastating consequences on health care systems. It is a global health priority to identify patients at risk of fatal outcomes. 1955 patients admitted to HM-Hospitales from 1 March to 10 June 2020 due to COVID-19, were were divided into two groups, 1310 belonged to the training cohort and 645 to validation cohort. Four different models were generated to predict in-hospital mortality. Following variables were included: age, sex, oxygen saturation, level of C-reactive-protein, neutrophil-to-platelet-ratio (NPR), neutrophil-to-lymphocyte-ratio (NLR) and the rate of changes of both hemogram ratios (VNLR and VNPR) during the first week after admission. The accuracy of the models in predicting in-hospital mortality were evaluated using the area under the receiver-operator-characteristic curve (AUC). AUC for models including NLR and NPR performed similarly in both cohorts: NLR 0.873 (95% CI: 0.849–0.898), NPR 0.875 (95% CI: 0.851–0.899) in training cohort and NLR 0.856 (95% CI: 0.818–0.895), NPR 0.863 (95% CI: 0.826–0.901) in validation cohort. AUC was 0.885 (95% CI: 0.885–0.919) for VNLR and 0.891 (95% CI: 0.861–0.922) for VNPR in the validation cohort. According to our results, models are useful in predicting in-hospital mortality risk due to COVID-19. The RIM Score proposed is a simple, widely available tool that can help identify patients at risk of fatal outcomes. View Full-Text
Keywords: COVID-19; neutrophil-to-platelet ratio; NPR; neutrophil-to-lymphocyte ratio; NLR; hemogram-derived-ratios COVID-19; neutrophil-to-platelet ratio; NPR; neutrophil-to-lymphocyte ratio; NLR; hemogram-derived-ratios
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MDPI and ACS Style

López-Escobar, A.; Madurga, R.; Castellano, J.M.; Velázquez, S.; Suárez del Villar, R.; Menéndez, J.; Peixoto, A.; Jimeno, S.; Ventura, P.S.; Ruiz de Aguiar, S. Risk Score for Predicting In-Hospital Mortality in COVID-19 (RIM Score). Diagnostics 2021, 11, 596. https://doi.org/10.3390/diagnostics11040596

AMA Style

López-Escobar A, Madurga R, Castellano JM, Velázquez S, Suárez del Villar R, Menéndez J, Peixoto A, Jimeno S, Ventura PS, Ruiz de Aguiar S. Risk Score for Predicting In-Hospital Mortality in COVID-19 (RIM Score). Diagnostics. 2021; 11(4):596. https://doi.org/10.3390/diagnostics11040596

Chicago/Turabian Style

López-Escobar, Alejandro, Rodrigo Madurga, José M. Castellano, Sara Velázquez, Rafael Suárez del Villar, Justo Menéndez, Alejandro Peixoto, Sara Jimeno, Paula S. Ventura, and Santiago Ruiz de Aguiar. 2021. "Risk Score for Predicting In-Hospital Mortality in COVID-19 (RIM Score)" Diagnostics 11, no. 4: 596. https://doi.org/10.3390/diagnostics11040596

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