Next Article in Journal
Electromyographic Patterns of Masticatory Muscles in Relation to Active Myofascial Trigger Points of the Upper Trapezius and Temporomandibular Disorders
Previous Article in Journal
Mini-Review Discussing the Reliability and Efficiency of COVID-19 Vaccines
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 11
Issue 4
10.3390/diagnostics11040581
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients

by
Stefano Salciccia
1,†,
Michael L. Eisenberg
2,†,
Martina Maggi
1,
Silvia Lai
3,
Claudio Maria Mastroianni
4,
Patrizia Pasculli
4,
Maria Rosa Ciardi
4,
Vittorio Canale
1,
Matteo Ferro
5,*,
Gian Maria Busetto
6,
Ettore De Berardinis
1,
Gian Piero Ricciuti
1,
Alessandro Sciarra
1,‡ and
Francesco Del Giudice
1,2,‡
1
Department of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
2
Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
3
Department of Translational and Precision Medicine, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
4
Department of Public Health and Infectious Diseases, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
5
Department of Urology, European Institute of Oncology (IEO), IRCCS, 20141 Milan, Italy
6
Department of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors contributed equally to this work.
Diagnostics 2021, 11(4), 581; https://doi.org/10.3390/diagnostics11040581
Submission received: 20 February 2021 / Revised: 13 March 2021 / Accepted: 18 March 2021 / Published: 24 March 2021
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
Browse Figures
Versions Notes

Abstract

Background: A growing body of evidence is emerging suggesting testosterone can affect all cells involved in the immune response to both bacterial and viral infections, and the testosterone effect on the immune response could explain the greater susceptibility of men to infections including COVID-19. We aimed to explore the predictive role of male serum total testosterone (TT) levels on the time till viral negativity testing among hospitalized COVID-19 patients. Methods: The univariate effect of risk factors for the duration of COVID-19 viral positivity was evaluated using the log-rank test and Kaplan–Meier estimates. A multivariable Cox regression model was developed to test the role of TT levels and the subsequent odds for shorter viral positivity intervals. Results: Increasing serum TT levels and the need for an oxygen administration strategy were independently predictive for respectively reduced and increased days to negativization (Hazard Ratio [HR]: 1.39, 95% CI: 0.95–2.03 and HR: 0.19, 95% CI: 0.03–1.18). Conclusion: Baseline higher TT levels for male COVID-19 patients at hospital admission are associated with shorter durations of positive COVID-19 testing and thus viral clearance. Our preliminary findings might play a relevant to help pandemic control strategies if these will be verified in future larger multicentric and possibly randomized trials.
Keywords: COVID-19; total testosterone; male serum testosterone; viral positivity duration; COVID-19 testing COVID-19; total testosterone; male serum testosterone; viral positivity duration; COVID-19 testing

Share and Cite

MDPI and ACS Style

Salciccia, S.; Eisenberg, M.L.; Maggi, M.; Lai, S.; Mastroianni, C.M.; Pasculli, P.; Ciardi, M.R.; Canale, V.; Ferro, M.; Busetto, G.M.; et al. Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients. Diagnostics 2021, 11, 581. https://doi.org/10.3390/diagnostics11040581

AMA Style

Salciccia S, Eisenberg ML, Maggi M, Lai S, Mastroianni CM, Pasculli P, Ciardi MR, Canale V, Ferro M, Busetto GM, et al. Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients. Diagnostics. 2021; 11(4):581. https://doi.org/10.3390/diagnostics11040581

Chicago/Turabian Style

Salciccia, Stefano, Michael L. Eisenberg, Martina Maggi, Silvia Lai, Claudio Maria Mastroianni, Patrizia Pasculli, Maria Rosa Ciardi, Vittorio Canale, Matteo Ferro, Gian Maria Busetto, and et al. 2021. "Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients" Diagnostics 11, no. 4: 581. https://doi.org/10.3390/diagnostics11040581

APA Style

Salciccia, S., Eisenberg, M. L., Maggi, M., Lai, S., Mastroianni, C. M., Pasculli, P., Ciardi, M. R., Canale, V., Ferro, M., Busetto, G. M., De Berardinis, E., Ricciuti, G. P., Sciarra, A., & Del Giudice, F. (2021). Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients. Diagnostics, 11(4), 581. https://doi.org/10.3390/diagnostics11040581

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop